This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

Does Disordered Sleep Moderate the Relationship Between Pain, Disability, and Downstream Healthcare Utilization in Patients with Low Back Pain? A Longitudinal Cohort from the US Military Health System

The purpose was to evaluate the influence of disordered sleep on the relationship between pain and healthcare utilization (HCU) and pain-related disability and HCU in individuals with low back pain (LBP).

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Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

Calcitonin gene–related peptide receptor has been implicated in the pathogenesis of migraine. Rimegepant is an orally administered, small-molecule, calcitonin gene–related peptide receptor antagonist that may be effective in acute migraine treatment.

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Thwack! Insects Feel Chronic Pain After Injury

A study in the peer-reviewed journal Science Advances offers the first genetic evidence of what causes chronic pain in fruit flies and there is good evidence that similar changes also drive chronic pain in humans. Full s...
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Rehab with Robots

A new generation of robotics is helping debilitated patients regain much of their former abilities by using technology that essentially communicates with muscles when the brain cannot. 

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Combined Online Self-Management for Pain, Associated Anxiety, and Depression Works

In a new paper published in the Journal of General Internal Medicine , researchers report that online symptom self-management works to decrease pain, anxiety, and depression symptoms. They also found that online symptom ...
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Discovery Suggests Potential New Target for Pain Control

The scientists, reporting in the journal Science , found that the production of prostaglandins in white blood cells depends on a signaling pathway known as IRE1α-XBP1, which is an important regulator of many cell functio...
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FDA Gives First-Ever Indication for Device to Be Used for Patients with Functional Abdominal Pain Associated with Irritable Bowel Syndrome (IBS)

The IB-Stim is a non-surgical device that is placed behind the patient's ear during an outpatient visit and works by sending gentle electrical impulses into cranial nerve bundles located in the ear.  Full story. &nb...
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Transfer of Complex Regional Pain Syndrome to Mice via Human Autoantibodies is Mediated by Interleukin-1–Induced Mechanisms.

 Complex regional pain syndrome (CRPS) is a poorly understood painful condition, which typically arises after distal limb trauma; 20% of patients may develop lifelong severe incessant pain with few therapeutic options. In this study, we show that immunoglobulin G autoantibodies from patients with severe, persistent CRPS, on transfer to hind paw-injured mice, elicit important features of the clinical condition and profound glial activation in pain-related brain regions. Blockade of the proinflammatory cytokine interleukin-1 (IL-1) both prevents and reverses these changes. Our findings suggest that antibody-mediated autoimmunity contributes to the development of severe CRPS after injury and that blockade of IL-1 actions may be an attractive therapeutic prospect. Investigation of autoantibody contribution to other unexplained chronic pain syndromes seems warranted.
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Association Between Medical Cannabis Laws and Opioid Overdose Mortality has Reversed Over Time

​Medical cannabis has been touted as a solution to the US opioid overdose crisis since Bachhuber et al. [M. A. Bachhuber, B. Saloner, C. O. Cunningham, C. L. Barry, JAMA Intern. Med. 174, 1668–1673] found that from 1999 to 2010 states with medical cannabis laws experienced slower increases in opioid analgesic overdose mortality. That research received substantial attention in the scientific literature and popular press and served as a talking point for the cannabis industry and its advocates, despite caveats from the authors and others to exercise caution when using ecological correlations to draw causal, individual-level conclusions.

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Associations Between Gabapentinoids and Suicidal Behavior, Unintentional Overdoses, Injuries, Road Traffic Incidents, and Violent Crime: Population Based Cohort Study in Sweden

Abstract: OBJECTIVE: To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, or both and road traffic incidents or offences), mental health (suicid...
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