This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

FDA Gives First-Ever Indication for Device to Be Used for Patients with Functional Abdominal Pain Associated with Irritable Bowel Syndrome (IBS)

The IB-Stim is a non-surgical device that is placed behind the patient's ear during an outpatient visit and works by sending gentle electrical impulses into cranial nerve bundles located in the ear.  Full story. &nb...
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Transfer of Complex Regional Pain Syndrome to Mice via Human Autoantibodies is Mediated by Interleukin-1–Induced Mechanisms.

 Complex regional pain syndrome (CRPS) is a poorly understood painful condition, which typically arises after distal limb trauma; 20% of patients may develop lifelong severe incessant pain with few therapeutic options. In this study, we show that immunoglobulin G autoantibodies from patients with severe, persistent CRPS, on transfer to hind paw-injured mice, elicit important features of the clinical condition and profound glial activation in pain-related brain regions. Blockade of the proinflammatory cytokine interleukin-1 (IL-1) both prevents and reverses these changes. Our findings suggest that antibody-mediated autoimmunity contributes to the development of severe CRPS after injury and that blockade of IL-1 actions may be an attractive therapeutic prospect. Investigation of autoantibody contribution to other unexplained chronic pain syndromes seems warranted.
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Association Between Medical Cannabis Laws and Opioid Overdose Mortality has Reversed Over Time

​Medical cannabis has been touted as a solution to the US opioid overdose crisis since Bachhuber et al. [M. A. Bachhuber, B. Saloner, C. O. Cunningham, C. L. Barry, JAMA Intern. Med. 174, 1668–1673] found that from 1999 to 2010 states with medical cannabis laws experienced slower increases in opioid analgesic overdose mortality. That research received substantial attention in the scientific literature and popular press and served as a talking point for the cannabis industry and its advocates, despite caveats from the authors and others to exercise caution when using ecological correlations to draw causal, individual-level conclusions.

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Associations Between Gabapentinoids and Suicidal Behavior, Unintentional Overdoses, Injuries, Road Traffic Incidents, and Violent Crime: Population Based Cohort Study in Sweden

Abstract: OBJECTIVE: To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, or both and road traffic incidents or offences), mental health (suicid...
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Trigeminal Autonomic Cephalalgias Presenting in a Multidisciplinary Tertiary Orofacial Pain Clinic

Abstract: Orofacial pain may have a variety of causes and offers a significant clinical challenge for its diagnosis and management. Objective: To assess the headache disorders presenting in a tertiary multidisciplinary o...
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Chronic Opioid Prescribing in Primary Care: Factors and Perspectives

Abstract: BACKGROUND: Primary care clinicians write 45% of all opioid prescriptions in the United States, but little is known about the characteristics of patients who receive them and the clinicians who prescribe opioid...
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To Save The Science Poster, Researchers Want To Kill It And Start Over

In the world of science and medicine, posters are a huge deal, but one doctoral student says poster sessions are usually a waste of time for all involved. So he has proposed a new poster design. Full story.
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Suicidal Thoughts Related to Pain in 1 in 10 Patients with Rheumatic or Musculoskeletal Disease

The results of a survey presented at the Annual European Congress of Rheumatology highlight the significant impact of rheumatic and musculoskeletal diseases (RMDs) on mental health and a worrying lack of psychological ca...
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Taming Tetrodotoxin: Pufferfish Venom Explored for Precise Painkilling

Researchers at Boston Children's Hospital have developed a novel way to deliver neurotoxin called tetrodotoxin (TTX) as a painkiller, and they have turned up some positive results from rat studies. Full story.
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Can You Reshape Your Brain's Response To Pain?

Repeated exposure to psychological trauma, or deep anxiety or depression — especially in childhood — can leave a physical imprint on the brain that can make some people more vulnerable to chronic pain, scientists say.&nb...
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