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November 8, 2018

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Gabapentinoid Use in the United States 2002 through 2015 (Research Letter)

Source: JAMA Internal Medicine
Gabapentin and pregabalin are the 2 clinically used medications in the gabapentinoid drug class. Pregabalin and gabapentin have both been approved by the US Food and Drug Administration for treatment of partial seizures and postherpetic neuralgia. Gabapentin enacarbil has also been approved for restless legs syndrome, while pregabalin has additional approvals for diabetic peripheral neuropathy, neuropathic pain associated with spinal cord injury, and fibromyalgia.
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Hyperactivity of Anterior Cingulate Cortex Areas 24a/24b Drives Chronic Pain-Induced Anxiodepressive-Like Consequences

Source: Journal of Neuroscience
Abstract: Pain associates both sensory and emotional aversive components, and often leads to anxiety and depression when it becomes chronic. Here, we characterized, in a mouse model, the long-term development of these sensory and aversive components as well as anxiodepressive-like consequences of neuropathic pain and determined their electrophysiological impact on the anterior cingulate cortex (ACC, cortical areas 24a/24b). We show that these symptoms of neuropathic pain evolve and recover in different time courses following nerve injury in male mice. In vivo electrophysiological recordings evidence an increased firing rate and bursting activity within the ACC when anxiodepressive-like consequences developed and this hyperactivity persists beyond the period of mechanical hypersensitivity.
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American Academy of Pain Medicine