As the opioid epidemic claims even more lives, medical schools are rethinking how they teach students to manage patients’ pain. The result? A better understanding of the nature of pain, addiction, and substance use disorder.
Source: Purdue University
A compound shows unparalleled selectivity in inhibiting the adenylyl cyclase 1 (AC1), making it a potential target for treating pain and reducing the dependency on opioids for pain management.
Source: Journal of Neuroscience
Abstract: Pain associates both sensory and emotional aversive components, and often leads to anxiety and depression when it becomes chronic. Here, we characterized, in a mouse model, the long-term development of these sensory and aversive components as well as anxiodepressive-like consequences of neuropathic pain and determined their electrophysiological impact on the anterior cingulate cortex (ACC, cortical areas 24a/24b). We show that these symptoms of neuropathic pain evolve and recover in different time courses following nerve injury in male mice. In vivo electrophysiological recordings evidence an increased firing rate and bursting activity within the ACC when anxiodepressive-like consequences developed and this hyperactivity persists beyond the period of mechanical hypersensitivity.
Source: University of Granada
A pioneering international study, carried out by the University of Granada, Harvard University, the University of California, Los Angeles (UCLA), the University of Florida, Laval University and the Jackson Laboratory has conducted an in-depth analysis of the molecular differences between the most common symptoms associated with neuropathic pain.
American Academy of Pain Medicine