Source: Disease Models & Mechanisms
Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin signaling, the functional locus of insulin signaling in diabetes-associated hypersensitivity remains obscure. Here, we used Drosophila nociception/nociceptive sensitization assays to investigate the role of Insulin receptor (Insulin-like receptor, InR) in nociceptive hypersensitivity.
Gabapentin tops pregabalin for pain reduction in patients with chronic sciatica, results of a head-to-head comparison show. But at least one expert has concerns about this conclusion.
American Academy of Pain Medicine