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Drosophila Insulin Receptor Regulates the Persistence of Injury-Induced Nociceptive Sensitization

Source: Disease Models & Mechanisms
Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin signaling, the functional locus of insulin signaling in diabetes-associated hypersensitivity remains obscure. Here, we used Drosophila nociception/nociceptive sensitization assays to investigate the role of Insulin receptor (Insulin-like receptor, InR) in nociceptive hypersensitivity.
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Pain Medicine Journal
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AAPM

American Academy of Pain Medicine