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Microstructural Changes in the Trigeminal Nerve of Patients With Episodic Migraine Assessed Using Magnetic Resonance Imaging

There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribute to migraine pathophysiology. Whilst it is not possible to explore the anatomy of small trigeminal nerve branches it is possible to explore the anatomy of the trigeminal root entry zone using magnetic resonance imaging in humans. The aim of this investigation is to assess the microstructure of the trigeminal nerve in vivo to determine if nerve alterations occur in individuals with episodic migraine.

Read the abstract.

Axsome Therapeutics Announces AXS-07 Achieves Co-Primary and Key Secondary Endpoints in MOMENTUM Phase 3 Migraine Trial in Patients with a History of Inadequate Response

Axsome Therapeutics, Inc., a clinical-stage biopharmaceutical company developing novel therapies for the management of central nervous system (CNS) disorders, today announced that AXS-07, Axsome’s novel, oral, multi-mechanistic investigational medicine for the acute treatment of migraine, met the two regulatory co-primary endpoints and significantly improved migraine pain and most bothersome symptoms as compared to placebo in the MOMENTUM Phase 3 trial.

June is National Migraine & Headache Awareness Month

Bring awareness and recognition of headache disorder as a legitimate neurobiological disease and help make individuals with headache disorder know that there are new treatments available. Read about the AAPM Foundation’s Migraine Consensus Guideline project and join AAPM’s Headache and Orofacial Pain Medicine Shared Interest Group.

In honor of National Migraine & Headache Awareness Month, the following related on-demand educational sessions, which were originally presented in conjunction with the AAPM 2018 and 2019 Annual Meeting, can be viewed for free in the AAPM Education Center during the month of June:

  • ​It Takes a Villiage to Raze a Headache: Interdisciplinary Management of Primary Headaches
  • Headache for the Pain Practitioner
  • Practical Manual Medicine Techniques to Use in the Office for Cervicogenic Headache and Sacroiliac Pain
  • Headache Evaluation & Management: Medical and Interventional Approaches
  • Not All Headaches Are Migraines! A Practical Approach to Cranial Neuralgias, Unilateral and Medication-Overuse Headaches

FDA Grants Theranica De Novo to Market First Smartphone-controlled Acute Migraine-relief Wearable Device

Theranica, a bio-medical technology company developing advanced electroceuticals for migraine and other pain disorders, announced today that the U.S. Food and Drug Administration (FDA) granted a De Novo request for its smartphone-controlled electroceutical, Nerivio Migra®, utilizing Remote Electrical Neuromodulation for the acute treatment of migraine. 

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American Academy of Pain Medicine