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Gabapentinoid

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Don’t Be the Don Quixote of Pain Management

AAPM Member and MedPage Today Pain Points blog contributor Heath McAnally, MD, discusses that the overzealous attention to gabapentinoids and its potential for non-indicated prescription, misuse, abuse and adverse effects. “We’re in a war against both chronic pain and really serious chemical coping in this country, and sometimes the lesser of two evils is a strategic necessity,” comments Dr. McAnally.

Associations Between Gabapentinoids and Suicidal Behavior, Unintentional Overdoses, Injuries, Road Traffic Incidents, and Violent Crime: Population Based Cohort Study in Sweden

Abstract: OBJECTIVE: To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, or both and road traffic incidents or offences), mental health (suicidal behaviour, unintentional overdoses), and criminality.

A Clinical Overview of Off-label Use of Gabapentinoid Drugs

The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain. For gabapentin, the only pain-related indication approved by the US Food and Drug Administration (FDA) is postherpetic neuralgia. For pregabalin, FDA-approved indications related to pain are limited to postherpetic neuralgia, neuropathic pain associated with diabetic neuropathy or spinal cord injury, and fibromyalgia.

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