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COVID-19

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Virtual Pain Care Management (COVID-19) (VCPM)

The COVID-19 pandemic is exacerbating the challenges faced by Veterans at risk of opioid overdose including Veterans prescribed moderate-to-high dose long-term opioid therapy (LTOT) whose usual treatment resources and coping strategies may be inaccessible. This project combines established VA care components to deploy and evaluate virtual models of care for Veterans on high-risk LTOT to meet the dual challenges of maintaining social distancing and delivery high quality care. Read more.

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2’s Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) – a pro-nociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. Read more.

Researchers Study Pain Relief Caused by Coronavirus

New research from the University of Arizona could explain why nearly half of all people who get coronavirus show few or no symptoms. The researchers discovered SARS-CoV-2, the virus that causes COVID-19, has the ability to reduce pain by blocking the pain pathway at the cellular level. Viruses infect cells through protein receptors, and coronavirus is no different. Read more.

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Pain Medicine Journal
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AAPM

American Academy of Pain Medicine