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Study Bolsters Patient-Controlled Analgesia for Cancer Pain

AAPM member Kenneth Candido, MD, comments on a study regarding patient-controlled analgesia (PCA) IV hydromorphone titration provides quicker analgesic effect, higher patient satisfaction and a similar tolerability compared with non-PCA administration in patients with severe cancer pain. The findings come from a phase 3, randomized clinical trial involving 214 patients that was presented at the American Society of Clinical Oncology. Read more.

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2’s Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) – a pro-nociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. Read more.

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