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Selective Modulation of Tonic Aversive Qualities of Neuropathic Pain by Morphine in the Central Nucleus of the Amygdala Requires Endogenous Opioid Signaling in the Anterior Cingulate Cortex

The amygdala is a key subcortical region thought to contribute to emotional components of pain. As opioid receptors are found in both the central (CeA) and basolateral (BLA) nuclei of the amygdala, we investigated the effects of morphine microinjection on evoked pain responses, pain motivated behaviors, dopamine release in the nucleus accumbens (NAc), and descending modulation in rats with left side spinal nerve ligation (SNL). Read the abstract.

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