1 minute reading time (42 words)

Predicting Inadequate Postoperative Pain Management in Depressed Patients: A Machine Learning Approach

Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSRIs), inhibits CYP-2D6 activity and therefore may reduce the effectiveness of prodrug opioids. Read the abstract

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