This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

Central Sensitization May Occur in Cluster Headache

Individuals with versus without cluster headache were found to have lower cranial and extracranial pressure pain thresholds, indicating central sensitization, according to a study published in Pain Medicine . Full story....
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Mole-Rat Pain Resistance Could Point the Way to New Analgesics

In a study published in Science , a team assessed the responses of eight kinds of mole-rats and two other rodent species to three substances that normally elicit pain: acid, capsaicin, and allyl isothiocyanate (AITC), th...
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Massage Reduces Pain among Inpatients

Integrative medicine services — primarily massage therapy — resulted in a significant reduction in pain among hospitalized patients, according to recent research at two Mayo Clinic hospitals. Full story.  

Improvements in Chronic Low Back Pain after Basivertebral Nerve Ablation

Patients who decreased opioid use after undergoing basivertebral nerve (BVN) ablation were found to experience greater relief of chronic low back pain than those who increased opioid use, according to a study published i...
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The Neuroinflammatory Component of Negative Affect in Patients with Chronic Pain

Abstract: Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patients is linked to elevations in the brain levels of the glial marker 18 kDa translocator protein (TSPO), and changes in functional connectivity. 25 cLBP patients (42.4 ± 13 years old; 13F, 12M) with chronic low back pain (cLBP) and 27 healthy control subjects (48.9 ± 13 years old; 14F, 13M) received an integrated (i.e., simultaneous) positron emission tomography (PET)/magnetic resonance imaging (MRI) brain scan with the second-generation TSPO ligand [11C]PBR28.

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Voltage-gated Sodium Channels: Structures, Functions, and Molecular Modeling

Abstract: Voltage-gated sodium channels (VGSCs), formed by 24 transmembrane segments arranged into four domains, have a key role in the initiation and propagation of electrical signaling in excitable cells. VGSCs are involved in a variety of diseases, including epilepsy, cardiac arrhythmias, and neuropathic pain, and therefore have been regarded as appealing therapeutic targets for the development of anticonvulsant, antiarrhythmic, and local anesthetic drugs.

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Medical Schools Look to Educate the Next Generation of Doctors on Pain

WBUR public radio interview discusses how some medical schools are changing the way students learn about pain and addiction.  Full story.  
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Walking Without Pain: How a New Surgical Procedure is Giving Hope to Some Amputees

An amputee recently became the third patient in Canada to undergo osseointegration, a relatively new procedure aimed at giving amputees higher functionality, mobility and comfort. Full story.  
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Study Shows Safety Initiative Decreases Opioid Use in VA Patients with Little Impact on Pain Scores

New research published in Anesthesiology reports that after an Opioid Safety Initiative (OSI) was implemented at the Veterans Health Administration, patients undergoing knee replacement surgery were prescribed significan...
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Can Tech 'Objectively' Assess Pain?

Some combination of data and machinery may, go the pronouncements of the tech world, do what millennia of humans have been unable to: accurately feel someone else's pain.  Full story.  

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