This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

A New Painkiller Nanomedicine to Bypass the Blood-Brain Barrier and the Use of Morphine

The clinical use of endogenous neuropeptides has historically been limited due to pharmacokinetic issues, including plasma stability and blood-brain barrier permeability. In this study, we show that the rapidly metaboliz...
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Predicting Inadequate Postoperative Pain Management in Depressed Patients: A Machine Learning Approach

Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSR...
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Prevention of Prescription Opioid Misuse and Projected Overdose Deaths in the United States

What is the projected effect of lowering incident nonmedical prescription opioid use on the future trajectory of the opioid overdose crisis in the United States?

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The Pain of Sleep Loss: A Brain Characterization in Humans

Sleep loss increases the experience of pain. However, the brain mechanisms underlying altered pain processing following sleep deprivation are unknown. Moreover, it remains unclear whether ecologically modest night-to-nig...
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Gender Bias in Pediatric Pain Assessment

Accurate assessment of pain is central to diagnosis and treatment in healthcare, especially in pediatrics. However, few studies have examined potential biases in adult observer ratings of children's pain. Read the abstra...
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Penn’s ‘Enhanced Recovery’ Protocol Reduces Opioid Use in Spinal Surgery Patients

A new study published in the Journal of Neurosurgery: Spine showed that when an ERAS protocol was employed—which optimizes patients' surgical care before, during, and after surgery, including patient education, post-oper...
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Training the Prescriber: An Institutional Effort to Reduce the Amount of Opioids Prescribed Following Lumbar Surgery

A new study shows that an educational program on opiate use and misuse, the role of the orthopedic prescriber, multimodal analgesia, and state laws regarding opioid prescription could change prescriber behavior and resul...
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Parents Worried About Risks, But Still Think Opioids Are Best for Kids’ Pain Relief, Nationwide Survey Shows

A new survey shows that parents remain conflicted about opioids: while more than half express concern their child may be at risk for opioid addiction, nearly two-thirds believe opioids are more effective at managing thei...
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Research Pushes Back on Benefits of Compounded Topical Pain Creams

AAPM Board Member, Steven P. Cohen, MD , along with researchers at Johns Hopkins Medicine and Walter Reed National released the results of a rigorous federally funded study mandated by Congress that showed no statistical...
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The New York Times Features a Series of Articles on Pain in Children

​Part I: Managing Children's Pain After Surgery Part II: Taking the Pain Out of Children's Shots Part III: Helping Children Conquer Chronic Pain  

The AAPM Annual Meeting offers education and networking opportunities for all members of the pain care team.

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