This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

UF Institute on Aging Study Shows Chronic Pain Might Accelerate Brain Aging

A new study led by a University of Florida Institute on Aging researcher has found the brain age of older adults with chronic pain had accelerated by an average of two years. 

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Neoline Is the Active Ingredient of Processed Aconite Root Against Murine Peripheral Neuropathic Pain Model, and Its Pharmacokinetics in Rats

 The present study investigated the effects of PA on a murine peripheral neuropathy model induced by intraperitoneal injection of paclitaxel and partial ligation of the sciatic nerve (Seltzer model), and identified its active ingredients.
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TRP Channels and Migraine: Recent Developments and New Therapeutic Opportunities.

Migraine is the second-most disabling disease worldwide, and the second most common neurological disorder. Attacks can last many hours or days, and consist of multiple symptoms including headache, nausea, vomiting, hypersensitivity to stimuli such as light and sound, and in some cases, an aura is present.

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Insular and Anterior Cingulate Cortex Deep Stimulation for Central Neuropathic Pain: Disassembling the Percept of Pain.

Objective: To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. 

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TRPV1 promotes opioid analgesia during inflammation

 Abstract: Pain and inflammation are inherently linked responses to injury, infection, or chronic diseases. Given that acute inflammation in humans or mice enhances the analgesic properties of opioids, there is much interest in determining the inflammatory transducers that prime opioid receptor signaling in primary afferent nociceptors.

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A Shot at Blocking Addiction

With the help of a NIH grant, University of New Mexico researchers are developing a vaccine that would block opioids from acting in the brain, a treatment that could play a key role in overcoming addiction. 

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Social Support Key to Remission from Suicidal Thoughts for Disabling Chronic Pain Sufferers

According to a new study, poverty and history of anxiety and depressive disorders were impediments to recovery from suicidal ideation. 

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Depression, Obesity, Chronic Pain Could be Treated by Targeting the Same Key Protein

Major depression, obesity and chronic pain are all linked to the effects of one protein, called FKBP51. Researchers have now developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. 

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Next-Generation Single-Dose Antidotes for Opioid Overdoses

Scientists report that they are developing single-dose, longer-lasting opioid antidotes using polymer nanoparticles. 

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How Pain Tolerance and Anxiety Seem to Be Connected

A rare disorder in which a 71-year-old woman experiences no pain or anxiety, raises questions about the links between physical and psychological pain. 

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The AAPM Annual Meeting offers education and networking opportunities for all members of the pain care team.

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