Objective: To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study.
Abstract: Pain and inflammation are inherently linked responses to injury, infection, or chronic diseases. Given that acute inflammation in humans or mice enhances the analgesic properties of opioids, there is much interest in determining the inflammatory transducers that prime opioid receptor signaling in primary afferent nociceptors.
According to a new study, poverty and history of anxiety and depressive disorders were impediments to recovery from suicidal ideation.
Major depression, obesity and chronic pain are all linked to the effects of one protein, called FKBP51. Researchers have now developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood.
Scientists report that they are developing single-dose, longer-lasting opioid antidotes using polymer nanoparticles.
A rare disorder in which a 71-year-old woman experiences no pain or anxiety, raises questions about the links between physical and psychological pain.
In a research letter in the new issue of JAMA Surgery, a team from the University of Michigan reports that providing special disposal bags doubled the percentage of patients who safely disposed of their unneeded opioids within six weeks of their operation.
Pairing music with ibuprofen improved analgesic outcomes in an inflammation pain mouse model by more than 90 percent, while the cannabidiol-music and galanin analog NAX 5055-music pairings significantly reduced inflammation by 70 percent.
Many people who use opioid medications long term do not produce enough testosterone or another important hormone, cortisol, according to a new study.