This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

Insular and Anterior Cingulate Cortex Deep Stimulation for Central Neuropathic Pain: Disassembling the Percept of Pain.

Objective: To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. 

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TRPV1 promotes opioid analgesia during inflammation

 Abstract: Pain and inflammation are inherently linked responses to injury, infection, or chronic diseases. Given that acute inflammation in humans or mice enhances the analgesic properties of opioids, there is much interest in determining the inflammatory transducers that prime opioid receptor signaling in primary afferent nociceptors.

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A Shot at Blocking Addiction

With the help of a NIH grant, University of New Mexico researchers are developing a vaccine that would block opioids from acting in the brain, a treatment that could play a key role in overcoming addiction. 

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Social Support Key to Remission from Suicidal Thoughts for Disabling Chronic Pain Sufferers

According to a new study, poverty and history of anxiety and depressive disorders were impediments to recovery from suicidal ideation. 

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Depression, Obesity, Chronic Pain Could be Treated by Targeting the Same Key Protein

Major depression, obesity and chronic pain are all linked to the effects of one protein, called FKBP51. Researchers have now developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. 

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Next-Generation Single-Dose Antidotes for Opioid Overdoses

Scientists report that they are developing single-dose, longer-lasting opioid antidotes using polymer nanoparticles. 

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How Pain Tolerance and Anxiety Seem to Be Connected

A rare disorder in which a 71-year-old woman experiences no pain or anxiety, raises questions about the links between physical and psychological pain. 

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To Keep Leftover Opioids Out of Harm’s Way, Give Surgery Patients Special Disposal Bags, Study Shows

In a research letter in the new issue of JAMA Surgery, a team from the University of Michigan reports that providing special disposal bags doubled the percentage of patients who safely disposed of their unneeded opioids within six weeks of their operation. 

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Pairing Music with Medication Offers Potential Therapeutic Strategy to Manage Pain

Pairing music with ibuprofen improved analgesic outcomes in an inflammation pain mouse model by more than 90 percent, while the cannabidiol-music and galanin analog NAX 5055-music pairings significantly reduced inflammation by 70 percent. 

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Another Possible Consequence of the Opioid Epidemic: Hormone Deficiencies

Many people who use opioid medications long term do not produce enough testosterone or another important hormone, cortisol, according to a new study. 

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The AAPM Annual Meeting offers education and networking opportunities for all members of the pain care team.

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