This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

A Clinical Overview of Off-label Use of Gabapentinoid Drugs

The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain. For gabapentin, the only pain-related indication approved by the US Food and Drug Administration (FDA) is postherpetic neuralgia. For pregabalin, FDA-approved indications related to pain are limited to postherpetic neuralgia, neuropathic pain associated with diabetic neuropathy or spinal cord injury, and fibromyalgia.

Continue reading

Medications to Treat Opioid Addiction Are Effective and Save Lives, But Barriers Prevent Broad Access and Use, Says New Report

A new report from the National Academies of Sciences, Engineering and Medicine, Medications for Opioid Use Disorder Save Lives , says that withholding or failing to have available medications for the treatment of OUD in ...
Continue reading
Topics:

Initial Opioid Prescriptions among U.S. Commercially Insured Patients, 2012–2017

 Background: The United States is undergoing a crippling opioid epidemic, spurred in part by overuse of prescription opioids by adults 25 to 64 years of age. Of concern are long-duration and high-dose initial prescriptions, which place the patients and their friends and relatives at heightened risk for long-term opioid use, misuse, overdose, and death.
Continue reading

Pain-Induced Negative Affect Is Mediated via Recruitment of the Nucleus Accumbens Kappa Opioid System.

 Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the ...
Continue reading

Trends and Patterns of Geographic Variation in Opioid Prescribing Practices by State, United States, 2006-2017

Importance : Risk of opioid use disorder, overdose, and death from prescription opioids increases as dosage, duration, and use of extended-release and long-acting formulations increase. States are well suited to respond ...
Continue reading
Topics:

New Target for Chronic Pain Relief Confirmed by Scientists

A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain. 

Continue reading
Topics:

Where Does Chronic Pain Begin? Scientists Close in on Its Origins

Researchers cataloged variations in RNA expression in the dorsal root ganglia cells of patients differing by pain state and sex. Using RNA sequencing, a specialized form of gene sequencing, on those DRG cells yielded a l...
Continue reading
Topics:

The Migraine Eye: Distinct Rod-Driven Retinal Pathways' Response to Dim Light Challenges the Visual Cortex Hyperexcitability Theory

Migraine-type photophobia, most commonly described as exacerbation of headache by light, affects nearly 90% of the patients. It is the most bothersome symptom accompanying an attack. Using subjective psychophysical asses...
Continue reading

Assessment of the FDA Risk Evaluation and Mitigation Strategy for Transmucosal Immediate-Release Fentanyl Products

 Did the US Food and Drug Administration's (FDA's) Transmucosal Immediate-Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) meet its goal of preventing inappropriate use of TIRF products, such a...
Continue reading
Topics:

Opioid Use in the Family May Influence Adolescents’ Opioid Risk after Surgery

The presence of one or more family members using long-term opioids before a procedure was associated with a higher likelihood that adolescents prescribed opioids for the first time would do the same, according to the fin...
Continue reading
Topics:

The AAPM Annual Meeting offers education and networking opportunities for all members of the pain care team.

Learn More