This section will include pain research in the news, general stories about research and findings, pain abstracts in the news, and PubMed abstracts

Phosphorylation-Deficient G-Protein-Biased μ-Opioid Receptors Improve Analgesia and Diminish Tolerance but Worsen Opioid Side Effects

Findings identify carboxyl-terminal multisite phosphorylation as key step that drives acute μ-opioid receptor desensitization and long-term tolerance. Read the abstract . 
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Microglia Promote Increased Pain Behavior Through Enhanced Inflammation in the Spinal Cord During Repeated Social Defeat Stress

Clinical studies indicate that psychosocial stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Read the abstract . 
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The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)

This article describes the current consensus proposal by the International Association for the Study of Pain (IASP) and the International Society of Physical and Rehabilitation Medicine (ISPRM) for a specific set of FPs of chronic pain, which will have to be empirically validated in a next step. Read the abstract . 
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Study Explores Dangerous Increase in Patients Mixing Opioids, Benzodiazepines or Z-Drugs

A new study found a startling 250 percent increase in Americans taking a dangerous combination of both opioids and benzodiazepines — a group of drugs commonly prescribed for pain, insomnia and anxiety — over a 15-year period. Full story .

Rerouting Nerves During Amputation Reduces Phantom Limb Pain Before It Starts

Doctors are pioneering the use of primary targeted muscle reinnervation (TMR) to prevent or reduce debilitating phantom limb and stump pain in amputees. Full story .

Stanford Researchers Discover the Brain Cells that Make Pain Unpleasant

A team of scientists at Stanford University has identified a bundle of brain cells in mice responsible for the latter — that is, the negative emotions of pain. Full story .

New Data Show Growing Complexity of Drug Overdose Deaths in America

The report from CDC's MMWR , analyzes the growing number of U.S. drug overdose deaths from 2013 to 2017, and by demographic and geographic characteristics from 2016 to 2017. Full story .  

Pain Abstracts

Association of Prescribed Opioids with Increased Risk of Community-Acquired Pneumonia Among Patients With and Without HIV What is the association between prescribed opioids and community-acquired pneumonia requiring hospitalization among patients living with and without HIV? Read the abstract. Gene Network Dysregulation in the Trigeminal Ganglia an...
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Managing Children’s Pain after Surgery

The first in a series of columns on pain in children in The New York Times discusses the changes occurring on how pediatric pain is managed. Full story .

New Medications Offer Improved Treatment for Alcohol Use Disorders, Chronic Pain, Mood Disorders

A team of researchers from Purdue University discovered that two peptides, which are naturally metabolic products of Rubisco, a large protein found in many plants like spinach, may aid in the development of new medications for people dealing with addictions. Full story .
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