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Association of Opioid-Related Adverse Drug Events with Clinical and Cost Outcomes among Surgical Patients in a Large Integrated Health Care Delivery System

Source: JAMA Surgery
Abstract: Importance: Opioids are commonly used for pain control during and after invasive procedures. However, opioid-related adverse drug events (ORADEs) are common and have been associated with worse patient outcomes. Conclusions and Relevance: Opioid-related adverse drug events were common among patients undergoing hospital-based invasive procedures and were associated with significantly worse clinical and cost outcomes. Hospital-acquired harm from ORADEs in the surgical patient population is an important opportunity for health systems to improve patient safety and reduce cost.

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