Pain-Induced Negative Affect Is Mediated via Recruitment of the Nucleus Accumbens Kappa Opioid System.

 Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes.Read the abstract.