Macrophage-Derived Insulin-Like Growth Factor-1 is a Key Neurotrophic and Nerve-Sensitizing Factor in Pain Associated with Endometriosis

Macrophages are central to the pathophysiology of endometriosis: they dictate the growth and vascularization of endometriosis lesions and more recently have been shown to promote lesion innervation. The aim of this study was to determine the mechanistic role of macrophages in producing pain associated with endometriosis.  

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AAPM

American Academy of Pain Medicine