NIH Clinical Trials, open periods for grants, etc.

Randomized Study of Electronic Health Record Defaults and Comparison Feedback to Effectively Decrease Opioid Prescription Pill Burden (NCT03825549)

In this study, the investigators will evaluate the effect of a health system initiative aiming to change clinician opioid prescribing behaviors using two behavioral economic interventions - default options and social comparison feedback on performance to clinicians. Read the details . 

Recovery Toolkits: Assessment of Pragmatic Behavioral Pain Medicine Delivered In Hospital After Surgery (NCT03828669)

Behavioral pain medicine is largely absent from perioperative pathways, and on post-surgical recovery units. The goal of this project was to develop and implement "Recovery Toolkits", physical branded bags presented to patients after surgery. The "Recovery Toolkits" include a descriptive brochure and orientation to the contents of the bag. "Recover...
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Mindful Action for Pain (NCT03800654)

Chronic pain, defined as persistent or episodic pain that does not resolve with treatment, affects up to 50% of Veterans, costs the nation between $560 and $635 billion dollars annually, and is associated with high rates of disability and low quality of life. According to the Veterans Health Administration (VHA), the goal of pain treatment is to im...
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Effects of Psilocybin in Post-Traumatic Headache (NCT03806985)

The purpose of this study is to investigate the effects of oral psilocybin in post-traumatic headache. Subjects will be randomized to receive placebo, low dose psilocybin, or high dose psilocybin on two separate test days approximately 14 days apart. Subjects will maintain a headache diary prior to, during, and after the treatments in order to docu...
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Somatosensory Profiles in Individuals With Persistent Musculoskeletal Pain and Inflammatory Bowel Disease (NCT03799471)

This study evaluates nervous system hypersensitivity in individuals with inflammatory bowel disease (IBD) and experiences of ongoing musculoskeletal (MSK) pain. Previous results and current literature suggest that MSK pain in IBD may be influenced by hypersensitivity of the central nervous system, termed central sensitization. However, specific mec...
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Light Treatment to Improve Symptom Management of Fibromyalgia Syndrome (NCT03794908)

The purpose of this study is to determine the effect a morning light treatment has on improving physical function, pain intensity, and pain sensitivity in people with fibromyalgia syndrome (FMS).  Read the details.

Arthroscopic Transosseous vs. Anchored Rotator Cuff Repair (NCT03797287)

This study will compare arthroscopic transosseous versus anchored rotator cuff repairs in terms of clinical outcomes, rotator cuff integrity, and cost-effectiveness. With the collection of patient-reported outcomes the health of patients undergoing each rotator cuff repair technique will be assessed. The aims of this study will be achieved through ...
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Multimodal Pain Therapy After Hernia Repair (NCT03792295)

This is a randomized, non-blinded study comparing the effects of multimodal pain management (ibuprofen, tylenol, and narcotics/oxycodone as needed) for relief of post-operative pain in patients who undergo hernia repair. Patients who present for elective hernia surgery will be randomized in a 1:1 fashion by pre-operative pain score into a multimoda...
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NCATS Announces HEAL Design Challenges to Inspire Innovative Opioid Crisis Solutions

  The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) invites innovators to submit novel design solutions for its ASPIRE (A Specialized Platform for Innovative Research Exploration) Design Challenges. The deadline to submit solutions is May 31.  Full story.

NIH Needs Your Innovative Research Ideas Through Our Newly Announced NIH HEAL Initiative Funding Opportunities

NIH leadership from across the agency has been working diligently over the past several months to identify areas of greatest opportunity for research to address the national opioid crisis. They've announced new funding opportunity announcements (FOAs), added to several of the more than 30 FOAs. Full story .