NIH Clinical Trials, open periods for grants, etc.

Mechanisms of Massage

The investigators have previously found moderately painful massage produces comparable changes in pain sensitivity as a conditioned pain modulation paradigm in healthy participants suggesting shared underlying mechanisms. The researchers aim to extend these findings by understanding the influence of expectation on these findings.

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Pulsed Electromagnetic Field (PEMF) Therapy for Post-Operative Pain Following Orthopedic Surgery

The primary objective of this study is to prospectively determine, at 10 days after orthopedic shoulder or knee surgery, if pulsed electromagnetic field (PEMF) therapy is beneficial in reducing patient-reported post-operative pain, as measured by visual analog scale (VAS). The amount of pain medication taken daily and the physical function outcome scores after surgery and PEMF treatment will also be measured. e

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A New Model to Reach Vulnerable Older Adults With Pain Self-Management Support

Study Description: Brief Summary: Learning chronic pain self-management skills can help patients improve daily functioning and quality of life, while avoiding risks associated with opioids and other pharmacological treat...
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Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH

Study Description: Brief Summary: This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild tr...
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Efficacy and Safety of VM202 in Painful Diabetic Peripheral Neuropathy - The HOPES Trial

Study Description: Brief Summary: A double-blind, randomized, placebo-controlled, single-center, 12-month phase 2 study designed to assess the safety and efficacy of VM202 as a replacement for opioid analgesics in opioid...
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Chronic Pain, Couples, and Physical Activity

Chronic pain affects more than 50 million adults in the United States (Dahlhamer, Lucas, Zelaya, Nahin, Mackey, DeBar et al., 2018) and is estimated to cost the nation more than $560 billion dollars each year (Gaskin &am...
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Pain, Psychological, and Endocannabinoid Responses to Yoga in Breast Cancer Survivors with Chemotherapy-Induced Neuropathic Pain

This study evaluates the acute effect of aerobic exercise and yoga on pain, plasma levels of endocannabinoids, and mood (i.e., mood disturbance and anxiety). Participants will complete three separate sessions on differen...
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Perioperative Lidocaine and Ketamine in Abdominal Surgery

 The investigators propose to test the hypothesis that perioperative infusions of lidocaine and/or ketamine reduce opioid consumption and pain scores in adults recovering from elective inpatient abdominal surgery.

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Mechanisms of Change in Adolescent Pain Self-Management

Brief Summary: The MOCAS Study aims to describe the mechanisms through which sleep deficiency affects youth responses to an online pain self-management intervention over a 6-month period. The study is a single arm trial ...
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Mind Body Therapy for the Treatment of Chronic Pain

 Brief Summary: The goal of this study is to determine if mind body therapies can help people suffering from chronic back pain. The study is a randomized, partially blinded trial examining the effectiveness of mind body interventions (treatment arms) in reducing disability from back pain and alleviating back pain in participants as compared to usual care (control arm ). The investigators will secondarily investigate whether mind body interventions improve participant quality of life and reduce the need for pain-related hospitalization.

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