Why Is Migraine More Common in Women? One Protein May Hold the Key

In research published online April 8 in the Journal of Neuroscience, the calcitonin gene-related peptide (CGRP) is implicated in the development of migraine symptoms caused pain responses in female rodents, but not in males, when introduced into the meninges, the protective tissue layers surrounding the brain. 

Continue reading

UF Institute on Aging Study Shows Chronic Pain Might Accelerate Brain Aging

A new study led by a University of Florida Institute on Aging researcher has found the brain age of older adults with chronic pain had accelerated by an average of two years. 

Continue reading
Topics:

Help AAPM and the AMA Opioid Task Force Identify Barriers in Treatment

As one of the organizations in the AMA Opioid Taskforce, AAPM is working with the American Medical Association (AMA) to gather information on barriers to treatment. AAPM and the AMA request 10-15 minutes of your time to ...
Continue reading

CDC Issues Key Clarification on Guideline for Prescribing Opioids for Chronic Pain

The American Society of Clinical Oncology, the American Society of Hematology, and the National Comprehensive Cancer Network® received a letter from the Centers for Disease Control and Prevention (CDC) clarifying the CDC Guideline for Prescribing Opioids for Chronic Pain on prescribing opioids to manage pain from certain conditions. 

Continue reading
Topics:

Join AAPM in Thanking the Following Companies for their Support

The AAPM Corporate Relations Council (CRC) is a distinguished community of healthcare professionals with a sustained interest in pain disorders and pain management. Thanks to these companies for supporting the Academy's goals and mission.

Continue reading

Cardiovascular Autonomic Function and Endogenous Pain Modulation

The study will investigate the influence of cardiovascular autonomic function on pain sensitivity at rest in patients with fibromyalgia and age- and sex-matched control, the influence of cardiovascular autonomic function...
Continue reading

TENS Efficacy on Acute Back Pain in an Emergency Department Triage

Transcutaneous Electrical Nerve Stimulation (TENS) devices produce a gentle electrical stimulation that when applied through pads applied directly to the skin, has a noticeable effect in reducing pain associated with various types of injuries and ailments.

Continue reading

Neoline Is the Active Ingredient of Processed Aconite Root Against Murine Peripheral Neuropathic Pain Model, and Its Pharmacokinetics in Rats.

 The present study investigated the effects of PA on a murine peripheral neuropathy model induced by intraperitoneal injection of paclitaxel and partial ligation of the sciatic nerve (Seltzer model), and identified its active ingredients.
Continue reading

TRP Channels and Migraine: Recent Developments and New Therapeutic Opportunities.

Migraine is the second-most disabling disease worldwide, and the second most common neurological disorder. Attacks can last many hours or days, and consist of multiple symptoms including headache, nausea, vomiting, hypersensitivity to stimuli such as light and sound, and in some cases, an aura is present.

Continue reading
Topics:

Insular and Anterior Cingulate Cortex Deep Stimulation for Central Neuropathic Pain: Disassembling the Percept of Pain.

Objective: To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study. 

Continue reading

TRPV1 promotes opioid analgesia during inflammation

 Abstract: Pain and inflammation are inherently linked responses to injury, infection, or chronic diseases. Given that acute inflammation in humans or mice enhances the analgesic properties of opioids, there is much interest in determining the inflammatory transducers that prime opioid receptor signaling in primary afferent nociceptors.

Continue reading

A Shot at Blocking Addiction

With the help of a NIH grant, University of New Mexico researchers are developing a vaccine that would block opioids from acting in the brain, a treatment that could play a key role in overcoming addiction. 

Continue reading
Topics:

Social Support Key to Remission from Suicidal Thoughts for Disabling Chronic Pain Sufferers

According to a new study, poverty and history of anxiety and depressive disorders were impediments to recovery from suicidal ideation. 

Continue reading

New Part D Opioid Overutilization Policies

CMS implemented new opioid policies for Medicare drug plans effective January 1, 2019. Medicare Part D enrollees who have not filled an opioid prescription recently (within the last 60 days) will be limited to up to a 7-...
Continue reading

AAPM35 On Demand Course Recordings Now Posted

Thank you to all of the faculty, attendees, and industry partners who contributed to the success of the AAPM 35th Annual Meeting & Preconferences held in Denver March 6-10, 2019. The following on demand courses that ...
Continue reading

AAPM Comments on AHRQ Key Questions for Systematic Review on Management of Primary Headaches in Pregnancy

Comments from the American Academy of Pain Medicine The American Academy of Pain Medicine thanks the Agency for the opportunity to comment on The Evidence-based Practice Center Program at the Agency for Healthcare Resear...
Continue reading

AAPM Foundation Convenes Opioid Reduction Consensus Panel

Pain management experts and patient advocates met this past week to begin developing clear evidence-informed guidance for healthcare clinicians on the reduction or elimination of opioids, when appropriate, for ...
Continue reading

FDA Identifies Harm Reported From Sudden Discontinuation of Opioid Pain Medicines

The U.S. Food and Drug Administration (FDA) has received reports of serious harm in patients who are physically dependent on opioid pain medicines suddenly having these medicines discontinued or the dose rapidly decreased. These include serious withdrawal symptoms, uncontrolled pain, psychological distress, and suicide. 

Continue reading
Topics:

2019-2020 AAPM Board of Directors Assumes Office

 AAPM is pleased to announce its 2019-2020 Board of Directors, who assumed office on Saturday, March 9, 2019.

Continue reading

Members Invited to Join AAPM Investigator Registry

Periodically AAPM is asked to provide names of possible research sites for industry-sponsored trials. If you are an AAPM member who is interested in being listed as a potential Principal Investigator and/or as a pot...
Continue reading

Depression, Obesity, Chronic Pain Could be Treated by Targeting the Same Key Protein

Major depression, obesity and chronic pain are all linked to the effects of one protein, called FKBP51. Researchers have now developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. 

Continue reading

Next-Generation Single-Dose Antidotes for Opioid Overdoses

Scientists report that they are developing single-dose, longer-lasting opioid antidotes using polymer nanoparticles. 

Continue reading

How Pain Tolerance and Anxiety Seem to Be Connected

A rare disorder in which a 71-year-old woman experiences no pain or anxiety, raises questions about the links between physical and psychological pain. 

Continue reading

To Keep Leftover Opioids Out of Harm’s Way, Give Surgery Patients Special Disposal Bags, Study Shows

In a research letter in the new issue of JAMA Surgery, a team from the University of Michigan reports that providing special disposal bags doubled the percentage of patients who safely disposed of their unneeded opioids within six weeks of their operation. 

Continue reading
Topics:

Pairing Music with Medication Offers Potential Therapeutic Strategy to Manage Pain

Pairing music with ibuprofen improved analgesic outcomes in an inflammation pain mouse model by more than 90 percent, while the cannabidiol-music and galanin analog NAX 5055-music pairings significantly reduced inflammation by 70 percent. 

Continue reading

Another Possible Consequence of the Opioid Epidemic: Hormone Deficiencies

Many people who use opioid medications long term do not produce enough testosterone or another important hormone, cortisol, according to a new study. 

Continue reading
Topics:

Enhanced Recovery After Spine Surgery: A Systematic Review.

Enhanced recovery after surgery (ERAS) is a multidimensional approach to improving the care of surgical patients using subspecialty- and procedure-specific evidence-based protocols. The literature provides evidence of the benefits of ERAS implementation, which include expedited functional recovery, decreased postoperative morbidity, reduced costs, and improved subjective patient experience.

Continue reading
Topics:

Robot an Effective Pain Management Tool for Premature Babies

 

Researchers have designed a therapeutic robot that simulates human skin-to-skin contact, helping reduce pain for babies in the neonatal intensive care unit.

Continue reading
Topics:

Association of a Risk Evaluation and Mitigation Strategy Program With Transmucosal Fentanyl Prescribing.

Transmucosal immediate-release fentanyl (TIRF) drugs are potent, rapid-acting opioids approved to treat breakthrough pain in patients with cancer who are tolerant to other around-the-clock opioid analgesics. In March 201...
Continue reading
Topics:

NIH to Test Experimental Drug to Curb Opioid Cravings

A clinical trial of an experimental drug designed to treat cravings associated with OUD has begun in the National Institutes of Health Clinical Center. The Phase I trial in healthy adults will assess the safety of the experimental compound, ANS-6637, and how it is processed in the body when given with another drug that is processed by the same liver enzyme pathway. 

Continue reading
Topics:

HHS Releases Additional $487 Million to States, Territories to Expand Access to Effective Opioid Treatment; 2019 SOR Grants Will Total $1.4 Billion

 

This funding will expand access to treatment that works, especially to medication-assisted treatment (MAT) with appropriate social supports.

Continue reading
Topics:

Aegis Science Corporation Presents Corporate Showcase at AAPM35

View the 30-minute webinar : Are drug interactions harming your patients? Enhance DDI identification and patient care with Interact Rx™ Presented by Josh Schrecker, Pharm.D., Clinical Scientist, Healthcare Services, Aegi...
Continue reading
Topics:
DDI

Loratadine for Improvement of Bone Pain in Patients with Chronic Granulocyte-Colony Stimulating Factor (G-CSF) Use

G-CSF causes a release of histamine that may be a cause of chronic bone pain. Loratadine targets histamine, and so may be effective in reducing bone pain.The researchers plan to prospectively assess the effectiveness of loratadine for chronic bone pain in patients with chronic G-CSF use.

Continue reading

PCSS Discussion Forum: A Quick, Evidence-Based Resource from Clinical Experts

The PCSS Discussion Forum provides the opportunity for health professionals to discuss clinical practices around substance use disorders and opioid use disorder with colleagues and addiction and pain experts. (Sign up is required.) 

Continue reading
Topics:

A Clinical Overview of Off-label Use of Gabapentinoid Drugs

The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain. For gabapentin, the only pain-related indication approved by the US Food and Drug Administration (FDA) is postherpetic neuralgia. For pregabalin, FDA-approved indications related to pain are limited to postherpetic neuralgia, neuropathic pain associated with diabetic neuropathy or spinal cord injury, and fibromyalgia.

Continue reading

Medications to Treat Opioid Addiction Are Effective and Save Lives, But Barriers Prevent Broad Access and Use, Says New Report

A new report from the National Academies of Sciences, Engineering and Medicine, Medications for Opioid Use Disorder Save Lives , says that withholding or failing to have available medications for the treatment of OUD in ...
Continue reading
Topics:

AHRQ Seeks Input on Headaches in Pregnancy and Acute Pain

The Agency for Healthcare Research and Quality (AHRQ) has posted key questions for the systematic review on Management of Primary Headaches in Pregnancy for comment through April 11, as well as a draft technical brief on...
Continue reading

Opioid Treatment Agreement and Prescription Drug Monitoring Program-New Bonus Points for MIPS

Two new bonus measures have been added to the Promoting Interoperability (PI) category in the MIPS (Merit-Based Incentive Payment System) program for 2019. The new measures are not required and do not contribute to the m...
Continue reading
Topics:

AAPM Comments on HHS Pain Management Best Practices Inter-Agency Task Force Draft Report

Comments from the American Academy of Pain Medicine (Docket HHS-OS-2018-0027-0001)

The American Academy of Pain Medicine (AAPM) wishes thank the HHS Pain Management Best Practices Inter-Agency Task Force for their dedication and efforts to improve pain care nationally. The document has been thoroughly reviewed by two major committees within AAPM: the Scientific Review and Guidelines Committee and the Behavioral Medicine Committee.

The emphasis on patient-centered and individualized care is appropriate, and special attention to particularly disadvantaged populations and often neglected populations such as children, adolescents, and older adults is appreciated.

A common theme throughout the HHS document is the inclusion of nearly all available options of treatments within a particular category with relative equal emphasis. While this approach provides a comprehensive review of the subjects, it is important to consistently acknowledge the level of evidence supporting any included therapies, as is the standard practice for the publishing of Practice Guidelines.

We provide below several key concerns and recommendations to improve the document and to better align its content with the biospsychosocial model of pain care and current evidence. We urge these recommendations be considered to improve the content of national policy and training needs for providers as well as information available for those who suffer chronic pain.

Continue reading

AAPM Commitment Statement on Countering the U.S. Opioid Epidemic

The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the increasing toll of the harms that can arise from opioid use disorder. As a...
Continue reading
Topics:

2019 AAPM Meeting Highlights from Medscape

Read articles about the latest pain research present at AAPM35 in Denver, March 6-10, 2019.

Continue reading

2019 AAPM Meeting Highlights from MedPage Today

 Read articles about the latest pain research present at AAPM35 in Denver, March 6-10, 2019. 

Continue reading

Initial Opioid Prescriptions among U.S. Commercially Insured Patients, 2012–2017

 Background: The United States is undergoing a crippling opioid epidemic, spurred in part by overuse of prescription opioids by adults 25 to 64 years of age. Of concern are long-duration and high-dose initial prescriptions, which place the patients and their friends and relatives at heightened risk for long-term opioid use, misuse, overdose, and death.
Continue reading

Pain-Induced Negative Affect Is Mediated via Recruitment of the Nucleus Accumbens Kappa Opioid System.

 Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the ...
Continue reading

Self-Management Interventions for Chronic Pain Relief With Cancer Survivors (NCT03867760)

This study will evaluate the efficacy of a recorded hypnosis intervention in reducing chronic pain among cancer survivors and will explore its biological and psychological mechanisms. 

Continue reading

2019 AAPM Meeting Highlights from Practical Pain Management

Read articles about the latest pain research present at AAPM35 in Denver, March 6-10, 2019. 

Continue reading

Trends and Patterns of Geographic Variation in Opioid Prescribing Practices by State, United States, 2006-2017

Importance : Risk of opioid use disorder, overdose, and death from prescription opioids increases as dosage, duration, and use of extended-release and long-acting formulations increase. States are well suited to respond ...
Continue reading
Topics:

New Target for Chronic Pain Relief Confirmed by Scientists

A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain. 

Continue reading
Topics:

These Tech Companies Aim to Cure Pain without Pills

AAPM Member Jennifer Hah, MD MS, comments in this CNBC article about the advantages of pain relieving devices, such as neuromodulation and other technologies. 

Continue reading

Opiates Prescribing for Knee Arthroscopies and ACL Reconstruction (NCT03876743)

The purpose of the study is to determine if opiates are required to achieve adequate analgesia after knee arthroscopy and ACL reconstruction in outpatient surgery.  The investigators hypothesize that patients are fr...
Continue reading
Topics: