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2021 AAPM Annual Meeting Thank You

Thank You for Your Continued Interest!

We’re pleased to keep bringing you the latest scientific and technical advancements in pain. Check out the 2021 Annual Meeting site to see what information is already available and what was presented last year.

2021 Annual Meeting

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If you have a new email or mailing address, please fill out our 2021 Annual Meeting mail list form below to provide us with that information or email us at [email protected].

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Microstructural Changes in the Trigeminal Nerve of Patients With Episodic Migraine Assessed Using Magnetic Resonance Imaging

There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribute to migraine pathophysiology. Whilst it is not possible to explore the anatomy of small trigeminal nerve branches it is possible to explore the anatomy of the trigeminal root entry zone using magnetic resonance imaging in humans. The aim of this investigation is to assess the microstructure of the trigeminal nerve in vivo to determine if nerve alterations occur in individuals with episodic migraine.

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IL-23 in Arthritic and Inflammatory Pain Development in Mice

The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lymphocyte-independent, inflammatory arthritis and pain models have a similar requirement for tumour necrosis factor (TNF), granulocyte macrophage-colony stimulating factor (GM-CSF), and C-C motif ligand 17 (CCL17). Given this correlation in cytokine requirements, we explored whether IL-23 might interact with this cytokine cluster in the control of arthritic and inflammatory pain.

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Interleukin-10 Resolves Pain Hypersensitivity Induced by Cisplatin by Reversing Sensory Neuron Hyperexcitability

Understanding the mechanisms that drive transition from acute to chronic pain is essential to identify new therapeutic targets. The importance of endogenous resolution pathways acting as a “brake” to prevent development of chronic pain has been largely ignored. We examined the role of IL-10 in resolution of neuropathic pain induced by cisplatin. In search of an underlying mechanism, we studied the effect of cisplatin and IL-10 on spontaneous activity (SA) in DRG neurons. Cisplatin (2 mg/kg daily for 3 days) induced mechanical hypersensitivity that resolved within 3 weeks.

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Development and Validation of a Prediction Tool for Pain Reduction in Adult Patients Undergoing Elective Lumbar Spinal Fusion: a Multicentre Cohort Study

On average, 56% of patients report a clinically relevant reduction in pain after lumbar spinal fusion (LSF). Preoperatively identifying which patient will benefit from LSF is paramount to improve clinical decision making, expectation management and treatment selection. Therefore, this multicentre study aimed to develop and validate a clinical prediction tool for a clinically relevant reduction in pain 1 to 2 years after elective LSF. 

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American Academy of Pain Medicine