Spinal Cord Stimulation Reduces Pain and Motor Symptoms in Parkinson's Disease Patients

A team of researchers in the United States and Japan reports that spinal cord stimulation measurably decreased pain and reduced motor symptoms of Parkinson's disease, both as a singular therapy and as a "salvage therapy"...
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Spinal Stimulators for Pain Relief Repurposed to Restore Touch in a Lost Limb

A new study from the University of Pittsburgh's Rehab Neural Engineering Labs finds spinal cord stimulators commonly used to relieve chronic pain could provide a straightforward and universal method for adding sensory fe...
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Transcutaneous Intercostal Nerve Stimulation in Spinal Cord Injury

The purpose of this study is to determine the safety, feasibility, and effectiveness of electric stimulation of the nerves along the intercostal nerves on pain and spasticity in spinal cord injury patients. Read the deta...
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Brain Activity in People With Chronic Neuropathic Pain and Spinal Cord Injury

The purpose of this research study is to learn more about how patterns of brain activity change during different thinking tasks and how these changes relate to the intensity and unpleasantness of the neuropathic pain that people with SCI experience.

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Improving Care of Chronic Pain Patients with Spinal Cord Stimulator Therapy Amidst the Opioid Epidemic

The US government and other key stakeholders including professional medical bodies have amended recommendations in recent years to emphasize using no opioids or the lowest effective dose of opioids needed for treatment o...
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Examination and Characterization of Burst Spinal Cord Stimulation on Cerebrospinal Fluid Cellular and Protein Constituents in Patient Responders with Chronic Neuropathic Pain: A Pilot Study

Patients with neuropathic pain have altered proteomic and neuropeptide constituents in cerebrospinal fluid (CSF) compared to controls. Tonic spinal cord stimulation (SCS) has demonstrated differential expression of neuro...
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Appropriate Referral and Selection of Patients with Chronic Pain for Spinal Cord Stimulation: European Consensus Recommendations and E‐Health Tool

Spinal cord stimulation (SCS) is an established treatment for chronic neuropathic, neuropathic‐like and ischaemic pain. However, the heterogeneity of patients in daily clinical practice makes it often challenging to dete...
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Cost-Effectiveness Model Shows Superiority of Wireless Spinal Cord Stimulation Implantation Without a Separate Trial

The authors in this study evaluated the cost-effectiveness of wireless spinal cord stimulation (Wireless SCS) with single stage "direct to permanent" implantation vs. screening with temporary electrodes and an external pulse generator followed by implantation of a system for long-term use (IPG SCS). 

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Sensory Innervation in Porous Endplates by Netrin-1 from Osteoclasts Mediates PGE2-Induced Spinal Hypersensitivity in Mice

Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear. Here the authors report that in mice, osteoclasts induce sensory innervation in the porous endplates which cont...
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Long-Term Safety and Efficacy of Closed-Loop Spinal Cord Stimulation to Treat Chronic Back and Leg Pain (Evoke): A Double-Blind, Randomised, Controlled Trial.

Summary: Background: Spinal cord stimulation has been an established treatment for chronic back and leg pain for more than 50 years; however, outcomes are variable and unpredictable, and objective evidence of the mechani...
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Identification of Spinal Afferent Nerve Endings in the Colonic Mucosa and Submucosa That Communicate Directly With the Spinal Cord: The Gut-Brain Axis.

  Abstract:  The major sensory nerve pathway between the colon and central nervous system (spinal cord and brain) that underlies the gut-brain axis, is via spinal afferent neurons, with cell bodies in dorsal ro...
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Patient Experience Comparing Tonic Vs. Burst Spinal Cord Stimulation For Chronic Pain

Researchers are evaluating if subjects who have already experienced tonic spinal cord stimulation would have a better pain relief status with burst spinal cord stimulation. Read the details .

Spinal Cord Stimulation Failure: Evaluation of Factors Underlying Hardware Explantation

Spinal cord stimulation has been shown to improve pain relief and reduce narcotic analgesic use in cases of complex refractory pain syndromes. However, a subset of patients ultimately undergoes removal of the spinal cord...
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FDA Approves Abbott's "Low Dose," Recharge-Free Spinal Cord Stimulation System with up to Ten Year Battery Life for People Living with Chronic Pain

Abbott (NYSE: ABT) today announced the U.S. Food and Drug Administration (FDA) has approved the company's Proclaim XR™ recharge-free neurostimulation system for people living with chronic pain. The Proclaim XR platform o...
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Spinal Cord Stimulation in Chronic Pain: Evidence and Theory for Mechanisms of Action

In this review, we reconstruct the available basic science and clinical literature that offers support for mechanisms of both paresthesia spinal cord stimulation (P-SCS) and paresthesia-free spinal cord stimulation (PF-S...
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Outcomes of Sympathetic Blocks in the Management of Complex Regional Pain Syndrome: A Retrospective Cohort Study

Background: Sympathetic dysfunction may be present in complex regional pain syndrome, and sympathetic blocks are routinely performed in practice. To investigate the therapeutic and predictive values of sympathetic blocks, the authors test the hypotheses that sympathetic blocks provide analgesic effects that may be associated with the temperature differences between the two extremities before and after the blocks and that the effects of sympathetic blocks may predict the success (defined as achieving more than 50% pain reduction) of spinal cord stimulation trials.  

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In Lab, SLU Researchers Flip Pain Switch in Spinal Cord Cells

Facing an urgent need for safer and more effective therapies for those suffering from debilitating pain, Saint Louis University researchers are on a mission to find a non-narcotic off-switch for pain.  Full story. &...
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Prospective Data Demonstrates Effective Pain Relief and Improved Function Using Medtronic's Evolve(SM) Workflow with Spinal Cord Stimulation

Medtronic today announced primary endpoint (3-month) results of the Vectors Post Market Clinical Study that demonstrated effective pain relief and improved function in patients with chronic intractable back and leg pain treated with spinal cord stimulation (SCS) utilizing the EvolveSM workflow

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2019 AAPM Meeting Highlights from MedPage Today

 Read articles about the latest pain research present at AAPM35 in Denver, March 6-10, 2019. 

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