NIH Study in Mice Explains How Brain Can Turn Pain Signals Up or Down

A new study in mice uncovered a previously unknown role that the central amygdala can play in upgrading or downgrading pain signals in the brain's circuitry. The study, published in Cell Reports , was conducted by resear...
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The Association of Early Life Stressors with Pain Sensitivity and Pain Experience at 22 Years

Early life stress (ELS) can significantly influence biological pathways associated with nociception, increasing vulnerability to future heightened pain sensitivity and subsequent risk of pain events. However, very little...
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Mechanisms of Massage

The investigators have previously found moderately painful massage produces comparable changes in pain sensitivity as a conditioned pain modulation paradigm in healthy participants suggesting shared underlying mechanisms. The researchers aim to extend these findings by understanding the influence of expectation on these findings.

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An Evolutionary Medicine Perspective on Pain and Its Disorders

Abstract: Enormous progress in understanding the mechanisms that mediate pain can be augmented by an evolutionary medicine perspective on how the capacity for pain gives selective advantages, the trade-offs that shaped t...
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