Opioid Prescribing Decreases after Learning of a Patient's Fatal Overdose

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Number of Opioid Prescriptions Remains Unchanged, Mayo Clinic Research Finds

Source: Mayo Clinic Despite increased attention to opioid abuse, prescriptions have remained relatively unchanged for many U.S. patients, research led by Mayo Clinic and published in The BMJ . Full story.
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Outpatient Opioid Prescriptions for Children and Opioid-Related Adverse Events

Source: Pediatrics Abstract: BACKGROUND AND OBJECTIVES: Little is known about opioid prescribing for children without severe conditions. We studied the prevalence of and indications for outpatient opioid prescriptions an...
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Study with Implications for Opioid Crisis Finds Opioids Raise Risk of Fracture Nonunion

Source: Louisiana State University Health Sciences Center Dr. Robert Zura, Professor and Chair of Orthopaedic Surgery at LSU Health New Orleans School of Medicine, was part of a research team reporting that not only may ...
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Structure of the µ-Opioid Receptor-Gi Protein Complex

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Inpatient Opioid Use and Insufficient Weaning Pre-Discharge May Increase Outpatient Opioid Prescriptions

Source: American Thoracic Society According to the University of Pittsburgh School of Medicine scientists who conducted the study, theirs is the first large-scale evaluation of the impact of in-hospital opioid prescribin...
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Less is More When it Comes to Prescription Opioids for Hospital Patients, Study Finds

Source: Yale School of Medicine In a pilot study published in JAMA Internal Medicine , Yale researchers significantly reduced doses of opioid painkillers given to hospital patients. By delivering the opioids with a shot ...
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Blacks, Whites Equally as Likely to Be Prescribed Opioids for Pain

Source: University of Michigan Racial disparities in pain management have been well-documented, with doctors historically more willing to prescribe opiates to whites than to other racial and ethnic groups. But in light o...
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Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats

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Association between Facility-Level Utilization of Non-pharmacologic Chronic Pain Treatment and Subsequent Initiation of Long-Term Opioid Therapy

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Safe Opioid Prescribing for Acute Noncancer Pain in Hospitalized Adults: A Systematic Review of Existing Guidelines

Source: Journal of Hospital Medicine Abstract: BACKGROUND: Pain is common among hospitalized patients. Inpatient prescribing of opioids is not without risk. Acute pain management guidelines could inform safe prescribing ...
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Storing and Disposing of Opioid Analgesics: What Does Our Medicine Tell Us?

Source: Annals of Internal Medicine Abstract: Background: Medication diversion represents the largest source of misused opioid analgesics (1). Unused opioid analgesics are seldom safely stored or disposed of (1–3), creat...
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Physician Prescribing of Opioids to Patients at Increased Risk of Overdose from Benzodiazepine Use in the United States

Source: JAMA Psychiatry Abstract: Importance: Recent increases in US opioid-related deaths underscore the need to understand drivers of fatal overdose. The initial prescription of opioids represents a critical juncture b...
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Stopping Long-Term Opioid Therapy Has No Effect on Pain

Source: OHSU Patients may experience no discernible difference in their level of pain after discontinuing the long-term use of opioids, new research suggests. Researchers examined the electronic health records of 600 pat...
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Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population

Source: JAMA Internal Medicine Abstract: Importance: Opioid-related mortality increased by 15.6% from 2014 to 2015 and increased almost 320% between 2000 and 2015. Recent research finds that the use of all pain medicatio...
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Association of Medical and Adult-Use Marijuana Laws with Opioid Prescribing for Medicaid Enrollees

Source: JAMA Internal Medicine Abstract: Importance: Overprescribing of opioids is considered a major driving force behind the opioid epidemic in the United States. Marijuana is one of the potential nonopioid alternative...
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Ketamine and Norketamine Attenuate Oxycodone Tolerance Markedly Less than that of Morphine: From Behaviour to Drug Availability

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Blue Cross Blue Shield Association Affirms Opioids Should Not Be Prescribed as First or Second Lines of Pain Therapy

Source: BCBSA The Blue Cross Blue Shield Association (BCBSA) National Council of Physician and Pharmacist Executives (NCPE) at its March meeting adopted a professional standard that opioids should not be prescribed as fi...
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Oxycodone Use Shifts in Australia After Tamper-Resistant Versions Introduced

Source: Canadian Medical Association Journal After the introduction of tamper-resistant oxycodone in Australia, dispensing rates for higher-strength formulations decreased for people younger than 65 years, but there was ...
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Association of Mental Health Conditions and Treatments with Long-Term Opioid Analgesic Receipt Among Adolescents

Source: JAMA, Pediatrics Abstract: Importance: Adults with mental health conditions are more likely than those without to receive long-term opioid therapy. Less is known about opioid therapy among adolescents, especially...
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Jennifer Whistler: On the Search for Safer Opioids

Source: UC Davis According to Jennifer Whistler, associate director of the UC Davis Center for Neuroscience, drug development is headed in the wrong direction. Trends favor synthetic opioids that may mitigate side-effect...
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Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain

Source: ClinicalTrials.gov Read more...
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Separating Side Effects Could Hold Key for Safer Opioids

Source: National Council on Alcoholism and Drug Dependence Scientists have discovered a way to separate the two effects of opioid pain relievers -- pain relief and breathing -- opening a window of opportunity to make eff...
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Opioid Prescribing Behavior of Interventional Radiologists Across the United States

Source: Journal of the American College of Radiology Abstract: Purpose: To study opioid prescribing behavior of US interventional radiologists (IRs). Conclusion: Most IRs write few, if any, prescriptions for Medicare ben...
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Patient-Centered Prescription Opioid Tapering in Community Outpatients with Chronic Pain

Source: JAMA Internal Medicine Beth D. Darnall, PhD; Maisa S. Ziadni, PhD; Richard L. Stieg, MD, MPH; Ian G. Mackey; Ming-Chih Kao, PhD, MD; Pamela Flood, MD, PhD Abstract: The risks associated with prescription opioids ...
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Prescription Opioids Increase Risk for Serious Infections

Source: Medscape Full story (login required)... View abstract in Annals of Internal Medicine ...
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Efficacy of Treatments for Opioid-induced Constipation: A Systematic Review and Meta-Analysis

Source: Clinical Gastroenterology and Hepatology Abstract: Background & Aims: Opioid induced constipation (OIC) is a common problem in patients on chronic opioid therapy for cancer-related and non-cancer related pain...
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Decline in Prescription Opioids Attributable to Decreases in Long-Term Use: A Retrospective Study in the Veterans Health Administration 2010–2016

Source: Journal of General Internal Medicine Abstract: Background: Improved understanding of temporal trends in short- and long-term opioid prescribing may inform efforts to curb the opioid epidemic. Conclusions: Opioid ...
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Intrathecal Morphine Microdose Method Sensory Changes

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Scientists Take a Big Step Toward Building a Better Opioid

Source: University of North Carolina School of Medicine For the first time, scientists at the University of North Carolina School of Medicine and collaborators solved the crystal structure of the activated kappa opioid r...
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Reduction of Opioid Use and Improvement in Chronic Pain in Opioid-Experienced Patients After Topical Analgesic Treatment: An Exploratory Analysis

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The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome

Source: Mayo Clinic Proceedings Abstract: Restless legs syndrome (RLS) is a distinct disorder, differing from chronic pain in many ways. Refractory RLS is characterized by unresponsiveness to dopamine agonists or alpha-2...
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