Euphorbia Bicolor (Euphorbiaceae) Latex Phytochemicals Induce Long-Lasting Non-Opioid Peripheral Analgesia in a Rat Model of Inflammatory Pain

The negative side effects of opioid-based narcotics underscore the search for alternative non-opioid bioactive compounds that act on the peripheral nervous system to avoid central nervous system-mediated side effects. Th...
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Finding Non-Opioid Alternatives for Cancer Pain

Even without specific opioid prescription guidelines for cancer patients, UC Davis Comprehensive Cancer Center uses various pain treatment strategies, ranging from blocking nerves and stimulating the spinal cord to injec...
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Taming Tetrodotoxin: Pufferfish Venom Explored for Precise Painkilling

Researchers at Boston Children's Hospital have developed a novel way to deliver neurotoxin called tetrodotoxin (TTX) as a painkiller, and they have turned up some positive results from rat studies. Full story.
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Lilly Announces Licensing Agreement for Non-Opioid Pain Asset from Centrexion Therapeutics

Eli Lilly and Company announced a license agreement to acquire the exclusive worldwide rights for CNTX-0290 from Centrexion Therapeutics Corporation, a company focused on developing non-opioid, non-addictive therapeutics for the treatment of chronic pain. CNTX-0290, is a novel, small molecule somatostatin receptor type 4 (SSTR4) agonist that is currently being studied in Phase 1 clinical testing as a potential non-opioid treatment for chronic pain conditions. 

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In Lab, SLU Researchers Flip Pain Switch in Spinal Cord Cells

Facing an urgent need for safer and more effective therapies for those suffering from debilitating pain, Saint Louis University researchers are on a mission to find a non-narcotic off-switch for pain.  Full story. &...
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