Sheffield Neuroscientists Reveal Link between Cell ‘Dark Matter’ and Chronic Nerve Pain

Sheffield Neuroscientists Reveal Link between Cell 'Dark Matter' and Chronic Nerve Pain A new study demonstrates for the first time a link between chronic neuropathic pain and levels of specific microRNA, part of the non...
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A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

TRPA1 is a chemosensory ion channel that functions as a sentinel for structurally diverse electrophilic irritants. Channel activation occurs through an unusual mechanism involving covalent modification of cysteine residu...
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Chronic Pain Research: Linking Psychology, Sociology, and Neuroscience

Despite its prevalence, scientists do not know why some people develop chronic pain. A new study approaches this question from all angles, exploring the role of money and the mind.

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Pain Abstracts

Association of Opioid Prescribing with Opioid Consumption after Surgery in Michigan. Read the abstract . Knee Pain as a Predictor of Structural Progression Over 4 Years: Data from the Osteoarthritis Initiative, a Prospec...
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Pain Can Be a Self-Fulfilling Prophecy

A new brain imaging study finds that expectations about pain intensity can become self-fulfilling prophecies. Surprisingly, those false expectations can persist even when reality repeatedly demonstrates otherwise, the st...
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Can Stimulating the Brain Treat Chronic Pain?

Researchers show they could target one brain region with a weak alternating current of electricity, enhance the naturally occurring brain rhythms of that region, and significantly decrease symptoms associated with chroni...
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Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent (NCT03681769)

Source: ClinicalTrials.gov Read the details .
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Sugar Pills Relieve Pain for Chronic Pain Patients

Source: Northwestern Now Northwestern Medicine scientists have shown they can reliably predict which chronic pain patients will respond to a sugar placebo pill based on the patients' brain anatomy and psychological chara...
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Ketamine’s Antidepressive Effects Tied to Opioid System in Brain

Source: Stanford Medicine The surprising finding of a new Stanford study may alter how new antidepressants are developed and administered in order to mitigate the risk of opioid dependence. Full story .

Revealing a Novel Nociceptive Network that Links the Subthalamic Nucleus to Pain Processing

Source: PubMed.gov Read the abstract .
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Abnormal Low-Frequency Oscillations Reflect Trait-Like Pain Ratings in Chronic Pain Patients Revealed Through a Machine Learning Approach

  Source: Journal of Neuroscience Abstract: Measures of moment-to-moment fluctuations in brain activity of an individual at rest has been shown to be a sensitive and reliable metric for studying pathological brain m...
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Brain Imaging: A Promising Biomarker for Pain

Source: Biomedical Journal of Scientific & Technical Research Abstract: Clinicians and researchers have the problem of objectively assessing the intensity and characteristics of pain. Furthermore, the widespread use ...
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The Hurt Blocker: Mike Hildebrand’s Groundbreaking Research on Chronic Pain

Hildebrand, a Neuroscience professor at Carleton, is trying to figure out, with the help of some graduate students, what's happening in the spinal cord to perpetuate chronic pain. Full story...
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Activating Two Receptors Along Chemical Pathways May Provide Pain Relief at a Lower Opioid Dose

Source: Johns Hopkins Medicine A team of researchers at Johns Hopkins have found that activating nerve cell receptors along two chemical pathways — one that has previously been linked to how the brain senses "itch" — may...
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In Vivo Brain GPCR Signaling Elucidated by Phosphoproteomics

Source: PubMed.gov Read more...  
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New ‘E-Dermis’ Brings Sense of Touch, Pain to Prosthetic Hands

Source: Johns Hopkins University Amputees often experience the sensation of a "phantom limb"—a feeling that a missing body part is still there. That sensory illusion is closer to becoming a reality thanks to a team of en...
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The Brain Is Able to Anticipate Painful Movements Following Injury

Source: The Physiological Society When people are injured, how does the brain adapt the body's movements to help avoid pain? New research published in The Journal of Physiology investigates this question. Full story... &...
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Top-Down Descending Facilitation of Spinal Sensory Excitatory Transmission from the Anterior Cingulate Cortex

Source: Nature Communications Abstract: Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem...
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Body’s 'Natural Opioids' Affect Brain Cells Much Differently than Morphine

Source: University of California, San Francisco A new study led by UC San Francisco scientists shows that brain cells, or neurons, react differently to opioid substances created inside the body – the endorphins responsib...
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Effect of Pain Neuroscience Education Combined with Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial

Source: JAMA Neurology Abstract: Importance: Effective treatments for chronic spinal pain are essential to reduce the related high personal and socioeconomic costs. Read more...
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Study Finds the Frequency of Alpha Brain Waves Could Be Used to Assess a Person's Predisposition to Pain

The frequency of alpha brain waves can be used as a measure of an individual's vulnerability to developing and experiencing pain, researchers at the University of Birmingham in the UK and University of Maryland in the US...
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Comorbidity Between Pain and Mental Illness – Evidence of a Bidirectional Relationship

Source: European Journal of Pain Abstract: Background: Pain from various locations in the body and mental illness are common and the comorbidity between the two is well known although the temporal relationship remains to...
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Encoding of Self-Referential Pain Catastrophizing in Posterior Cingulate Cortex in Fibromyalgia

Source: PubMed.gov Read more...
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Chronic Pain Impairs Cognitive Flexibility and Engages Novel Learning Strategies in Rats

Source: PubMed.gov Read more...
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UNB Researchers Test Virtual Reality to Treat Phantom Pain

Source: University of New Brunswick, CA Researchers at the University of New Brunswick's Institute of Biomedical Engineering are studying whether virtual reality helps patients quiet the signals that cause phantom pain. ...
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Identification of Brain Region Responsible for Alleviating Pain Could Lead to Development of Opioid Alternatives

Source: University of Cambridge The team, led by the University of Cambridge, have pinpointed an area of the brain that is important for endogenous analgesia – the brain's intrinsic pain relief system. Their results, pub...
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Brain-to-Brain Coupling During Handholding Is Associated with Pain Reduction

Source: PubMed.gov Read more...

Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants with Serotonin Syndrome

Source: PubMed.gov Read more...

Head Movements and Postures as Pain Behavior

Source: PLOS One Abstract: Pain assessment can benefit from observation of pain behaviors, such as guarding or facial expression, and observational pain scales are widely used in clinical practice with nonverbal patients...
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Altered Pain Processing After Opioid Discontinuation

Source: Society for Neuroscience An imaging study of the brain and spinal cord published in JNeurosci reveals pain processing changes in healthy men after receiving a short-term application of a strong opioid. The resear...
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