The purpose of this research study is to learn more about how patterns of brain activity change during different thinking tasks and how these changes relate to the intensity and unpleasantness of the neuropathic pain that people with SCI experience.
The Sigma-1 receptor (σ1R) is highly expressed in the primary sensory neurons (PSNs) that are the critical site of initiation and maintenance of pain following peripheral nerve injury.
Researchers at The University of Texas at Dallas have pinpointed a single biochemical pathway as a target for addressing both this neuropathic pain and the accompanying cognitive problems.
Abstract: Managing neuropathic pain in patients with advanced cancer can be challenging: it often requires an adjuvant analgesic and what works for one person may not work for another. Pain that is unresponsive to pharmacological approaches may require interventional procedures that are not usual in pain management. The effect of neuropathic cancer pain on patients is multidimensional and requires a multidisciplinary approach. Nurses play a key role in assessing the severity of the pain and its impact on quality of life, along with managing treatments.
Abstract: Voltage-gated sodium channels (VGSCs), formed by 24 transmembrane segments arranged into four domains, have a key role in the initiation and propagation of electrical signaling in excitable cells. VGSCs are involved in a variety of diseases, including epilepsy, cardiac arrhythmias, and neuropathic pain, and therefore have been regarded as appealing therapeutic targets for the development of anticonvulsant, antiarrhythmic, and local anesthetic drugs.
Steroid injections, nerve stimulators and spinal fusions were no match for the chronic pain in Tammy Durfee's left side. After a decade searching for relief, a four-hour procedure using focused ultrasound put her pain to rest.
Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the development of mechanical hyperalgesia in neuropathic and inflammatory pain models in mice.
Objective: To compare the analgesic effects of stimulation of the anterior cingulate cortex (ACC) or the posterior superior insula (PSI) against sham deep (d) repetitive (r) transcranial magnetic stimulation (TMS) in patients with central neuropathic pain (CNP) after stroke or spinal cord injury in a randomized, double-blinded, sham-controlled, 3-arm parallel study.