Benefits and Harms of Pregabalin in the Management of Neuropathic Pain: A Rapid Review and Meta-Analysis of Randomized Clinical Trials

Pregabalin has beneficial effects on some symptoms of neuropathic pain. However, its use significantly increases the risk of a number of adverse events and discontinuation due to adverse events. The quality of the evidence from journal publications is low. Read the abstract . 

The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions

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Gabapentin May Top Pregabalin for Sciatica Pain

Source: Medscape Gabapentin tops pregabalin for pain reduction in patients with chronic sciatica, results of a head-to-head comparison show. But at least one expert has concerns about this conclusion. Full story .

Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome (NCT03616262)

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Ablation of PM20D1 Reveals N-Acyl Amino Acid Control of Metabolism and Nociception

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Drosophila Insulin Receptor Regulates the Persistence of Injury-Induced Nociceptive Sensitization

Source: Disease Models & Mechanisms Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin signaling, the functional locus of insulin signaling in diabetes-associated hypersensitivity remains obscure. Here, we used Droso...
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Disruption of nNOS-NOS1AP Protein-Protein Interactions Suppresses Neuropathic Pain in Mice

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Neuroinflammation of the Spinal Cord and Nerve Roots in Chronic Radicular Pain Patients

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Control of Mechanical Pain Hypersensitivity in Mice through Ligand-Targeted Photoablation of TrkB-Positive Sensory Neurons

Source: Nature Communications Abstract: Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expr...
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Direct Electrical Current Used to Preferentially Inhibit Pain-Transmitting Neurons

Source: Johns Hopkins Medicine Using computer models and laboratory rats, Johns Hopkins researchers have demonstrated that "direct electrical current" can be delivered to nerves preferentially, blocking pain signals while leaving other sensations undisturbed. Full story...

Palmitoylation of δ-Catenin Promotes Kinesin-Mediated Membrane Trafficking of Nav1.6 in Sensory Neurons to Promote Neuropathic Pain

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Inhibition of Neuronal FLT3 Receptor Tyrosine Kinase Alleviates Peripheral Neuropathic Pain in Mice

Source: Nature Communications Abstract: Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root ganglia that project to the dorsal spinal cord is a key physiopathological process. Here, we show that hematopoietic cells present at the nerve injury si...
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Nervous System Discovery Could Inform Stroke, Pain Therapies

Source: Oregon Health & Science University New research published in the journal Nature for the first time reveals the atomic structure of a key molecular component of the nervous system. Scientists at OHSU used advanced imaging techniques to ascertain the resting state of an acid-sensing ion channel. Full story...

Cannabis Products for Adults with Chronic Neuropathic Pain

Source: Cochrane Bottom line: There is a lack of good evidence that any cannabis-derived product works for any chronic neuropathic pain. Background: Neuropathic pain is pain coming from damaged nerves. It is different from pain messages that are carried along healthy nerves from damaged tissue (for example, a fall, or cut, or arthritic knee). Neuro...
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Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain

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Genetic Study Paves Way for New Neuropathic Pain Treatments

Source: University of Granada A pioneering international study, carried out by the University of Granada, Harvard University, the University of California, Los Angeles (UCLA), the University of Florida, Laval University and the Jackson Laboratory has conducted an in-depth analysis of the molecular differences between the most common symptoms associ...
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Hyperactivity of Anterior Cingulate Cortex Areas 24a/24b Drives Chronic Pain-Induced Anxiodepressive-Like Consequences

Source: Journal of Neuroscience Abstract: Pain associates both sensory and emotional aversive components, and often leads to anxiety and depression when it becomes chronic. Here, we characterized, in a mouse model, the long-term development of these sensory and aversive components as well as anxiodepressive-like consequences of neuropathic pain and...
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Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

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Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

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Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury

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Gabapentinoid Use in the United States 2002 through 2015 (Research Letter)

Source: JAMA Internal Medicine Gabapentin and pregabalin are the 2 clinically used medications in the gabapentinoid drug class. Pregabalin and gabapentin have both been approved by the US Food and Drug Administration for treatment of partial seizures and postherpetic neuralgia. Gabapentin enacarbil has also been approved for restless legs syndrome,...
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