What We Know So Far About How COVID Affects the Nervous System

Many of the symptoms experienced by people infected with SARS-CoV-2 involve the nervous system. Patients complain of headaches, muscle and joint pain, fatigue and "brain fog," or loss of taste and smell — all of which ca...
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Chronic Pain Releases Parabrachial Activity from Central Amygdala Inhibition

Chronic pain is a complex neurologic condition that involves both sensory and affective components. A crucial integrator of pain-related sensation and affect may be a set of neurons within the parabrachial nucleus. Read ...
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The Prevalence of Restless Legs Syndrome in Patients with Migraine: A Systematic Review and Meta-Analysis

Migraine is a severe and debilitating neurologic disorder and is claimed to be the sixth disabling illness in the world. This study aimed to determine the overall prevalence of restless legs syndrome (RLS) in patients wi...
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Neurobiologist Finds Potent Pain-Suppression Center in the Brain

A Duke University research team has found a small area of the brain in mice that can profoundly control the animals' sense of pain. The researchers found that general anesthesia also activates a specific subset of inhibi...
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Sigma-1 Receptor Activity in Primary Sensory Neurons Is a Critical Driver of Neuropathic Pain

The Sigma-1 receptor (σ1R) is highly expressed in the primary sensory neurons (PSNs) that are the critical site of initiation and maintenance of pain following peripheral nerve injury.  

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Researchers Gain New Insights into Pain Signaling in the Brain

In a new study, researchers from the University of Copenhagen have mapped how a potent neuropeptide binds to a brain receptor involved in causing human pain. The researchers expect that the mechanism could be exploited a...
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McGill Researchers End Decade-Long Search for Mechanical Pain Sensor

Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new...
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Quality Improvement in Dementia Care

The Dementia Management Quality Measurement Set was first developed and released in 2013 by the PCPI Foundation. Developed by an appointed multistakeholder technical expert panel (TEP), the 2013 Measurement Set was suppo...
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Magnetic Resonance Imaging of Neuroinflammation in Chronic Pain: A Role for Astrogliosis?

Non-invasive measures of neuroinflammatory processes in humans could substantially aid diagnosis and therapeutic development for many disorders, including chronic pain. Several proton Magnetic Resonance Spectroscopy (H-M...
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Perturbing the Activity of the Superior Temporal Gyrus During Pain Encoding Prevents the Exaggeration of Pain Memories: A Virtual Lesion Study Using Single-Pulse Transcranial Magnetic Stimulation

Past studies have shown that pain memories are often inaccurate, a phenomenon known as mnemonic pain bias. Pain memories are thought to play an important role on how future pain is felt. Recent evidence from our laborato...
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Neurofeedback Impact on Veterans With mTBI

This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCS...
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Long Term Efficacy of Neuronavigation Guided rTMS in Alleviating Gulf War Illness Related Headaches and Pain Symptoms

This study aims to look at the long term efficacy of using repetitive transcranial magnetic stimulation (rTMS) in relieving Gulf War Illness related headaches and pain. 

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Feasibility of Near-Infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling

The benefit experienced by some patients when treated with dry needling,1 combined with the field-expedient nature of this intervention, make dry needling uniquely suited for the military healthcare environment. An impro...
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New Discovery: How Chronic Pain Changes Your Brain and Personality

Australian researchers have found that people with chronic pain experience physical alterations in their brain that likely leads to negative changes in their personality. The study discovered that people with chronic pai...
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Tonic Suppression of the Mesolimbic Dopaminergic System by Enhanced Corticotropin-Releasing Factor Signaling Within the Bed Nucleus of the Stria Terminalis in Chronic Pain Model Rats

Although dysfunction of the mesolimbic dopaminergic system has been implicated in chronic pain, the underlying mechanisms remain to be elucidated. We hypothesized that increased inhibitory inputs to the neuronal pathway ...
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Inflammation Amps Up Neurite Growth, Gene Expression Involved in Heat, Cold Sensitivity

Researchers from North Carolina State University have found that inflammation increases neuronal activity, gene expression and sensory nerve (neurite) outgrowth in neurons involved in thermal – but not physical– sensatio...
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Pain Neurology

Abstract: Pain is often the initial complaint for which patients seek medical care presenting both a diagnostic and therapeutic challenge to the primary care provider. The appreciation of pain is not merely the result of...
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