Microstructural Changes in the Trigeminal Nerve of Patients With Episodic Migraine Assessed Using Magnetic Resonance Imaging

There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribute to migrai...
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Effect of Yoga as Add-On Therapy in Migraine

This abstract evaluated the effectiveness of yoga as an adjuvant to conventional medical management on clinical outcomes in patients with migraine. 

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Ketamine for Migraine in the Emergency Department

Ketamine is utilized often in the emergency department (ED) for rapid sequence intubation, procedural sedation, and acute pain management. The treatment of migraine headache in the ED varies widely and is dependent on se...
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Opioid Use to Treat Migraine Headaches in Hospitalized Children and Adolescents

Prescription of opioids to treat pediatric migraine is explicitly discouraged by treatment guidelines but persists in some clinical settings. We sought to describe rates of opioid administration in pediatric migraine hos...
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Intra-Arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache

The purpose of this study is to evaluate the safety and efficacy of intra-arterial (IA) delivery of Dexamethasone and Ketorolac into the arteries supplying the sphenopalatine ganglion (SPG) in patients with refracto...
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Unmet Needs in the Acute Treatment of Migraine Attacks and the Emerging Role of Calcitonin Gene–Related Peptide Receptor Antagonists

Migraine is a prevalent and chronic disease associated with high rates of disability and significant financial and socioeconomic burden. Current acute treatments for migraine attacks include both migraine-specific a...
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Manual Acupuncture for Migraine

The same pathways that transmit the caress of a lover can backfire and cause neuropathic pain. This pain is due to damage or disease affecting the sensory systems. Migraine is one of the most common and disabling ne...
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Mindfulness an Effective Treatment for Migraines, UMSOD Scientist Finds

A recently published article in Pain details how mindfulness — a concept derived from a 2,000-year-old Eastern practice — "is an effective treatment option for episodic migraine."

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A Comprehensive Review of Over-The-Counter Treatment for Chronic Migraine Headaches

Migraine headaches are a neurologic disorder characterized by attacks of moderate to severe throbbing headache that are typically unilateral, exacerbated by physical activity, and associated with phonophobia, photophobia...
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FDA Approves Lundbeck’s Vyepti™ (eptinezumab-jjmr) – the First and Only Intravenous Preventive Treatment for Migraine

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Efficacy, Safety, and Acceptability of Pharmacologic Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-Analysis

 What are the most effective, safe, and accepted pharmacologic treatments for migraine prophylaxis in children and adolescents?

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Tactile Pain Is Amplified and Pleasure Dulled for Migraine Patients

A new study has investigated sensual alterations in people living with migraine. The paper highlighted that tactile stimuli may feel more painful for migraineurs, while pleasurable sensations are dulled. 

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Lilly's REYVOW™ (lasmiditan) C-V, the First and Only Medicine in a New Class of Acute Treatment for Migraine (ditan), Now Available for Prescription

Eli Lilly and Company announced today that REYVOW™ (lasmiditan) C-V 50 mg and 100 mg tablets, an oral medication for the acute treatment of migraine with or without aura in adults, is now available for prescription and w...
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Nightly Sleep Duration, Fragmentation, and Quality and Daily Risk of Migraine.

  Abstract:  Objective: To test the hypotheses that insufficient duration, high fragmentation, and poor sleep quality are temporally associated with migraine onset on the day immediately following the sleep per...
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Axsome Therapeutics Announces AXS-07 Achieves Co-Primary and Key Secondary Endpoints in MOMENTUM Phase 3 Migraine Trial in Patients with a History of Inadequate Response

Axsome Therapeutics, Inc., a clinical-stage biopharmaceutical company developing novel therapies for the management of central nervous system (CNS) disorders, today announced that AXS-07, Axsome's novel, oral, multi-mech...
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Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine

 Is ubrogepant, an oral calcitonin gene–related peptide receptor antagonist, effective in the acute treatment of migraine?

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A New Link Between Migraines, Opioid Overuse May Be Key to Treating Pain

Researchers at the University of Illinois at Chicago and colleagues discovered that a peptide — small chains of amino acids that can regulate many behaviors and brain signaling pathways — links together migraine pain and...
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Remote Electrical Neuromodulation (REN) for the Acute Treatment of Migraine

There is a significant unmet need for novel, effective, and well‐tolerated acute migraine treatments. Remote electrical neuromodulation (REN) is a non‐pharmacological, non‐invasive, acute migraine treatment that stimulat...
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FDA Approves New Treatment for Patients with Migraine

The U.S. Food and Drug Administration approved Reyvow (lasmiditan) tablets for the acute (active but short-term) treatment of migraine with or without aura (a sensory phenomenon or visual disturbance) in adults. Reyvow i...
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Self-Motion Perception Is Sensitized in Vestibular Migraine: Pathophysiologic and Clinical Implications

Vestibular migraine (VM) is the most common cause of spontaneous vertigo but remains poorly understood. We investigated the hypothesis that central vestibular pathways are sensitized in VM by measuring self-motion percep...
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Facial Presentations of Migraine, TACs, and Other Paroxysmal Facial Pain Syndromes

The objective of this study was to assess the prevalence of facial pain (V2 and/or V3) presentations among nearly 3,000 patients with headache treated in a university tertiary care center.

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New Data for Migraine Treatment

  New research showed that, overall, opioids are being used in place of medicines that are approved and indicated to treat migraine – particularly among those who experience migraine headaches more frequently. ...
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Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

Calcitonin gene–related peptide receptor has been implicated in the pathogenesis of migraine. Rimegepant is an orally administered, small-molecule, calcitonin gene–related peptide receptor antagonist that may be effective in acute migraine treatment.

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June is National Migraine & Headache Awareness Month

Bring awareness and recognition of headache disorder as a legitimate neurobiological disease and help make individuals with headache disorder know that there are new treatments available. Read about the AAPM Foundation's...
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FDA Grants Theranica De Novo to Market First Smartphone-controlled Acute Migraine-relief Wearable Device

Theranica, a bio-medical technology company developing advanced electroceuticals for migraine and other pain disorders, announced today that the U.S. Food and Drug Administration (FDA) granted a De Novo request for its smartphone-controlled electroceutical, Nerivio Migra®, utilizing Remote Electrical Neuromodulation for the acute treatment of migraine. 

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Oral CGRP Drug Bests Placebo for Migraine Prevention

Atogepant, an investigational oral calcitonin gene-related peptide (CGRP) receptor antagonist for migraine prevention, led to fewer monthly migraine days in episodic monthly migraine patients, results of a phase IIb/III ...
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Remote Electrical Neuromodulation (REN) Relieves Acute Migraine: A Randomized, Double‐Blind, Placebo‐Controlled, Multicenter Trial

There is a significant unmet need for novel effective well‐tolerated acute migraine treatments. REN is a novel acute migraine treatment that stimulates upper arm peripheral nerves to induce conditioned pain modulation – ...
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Why Is Migraine More Common in Women? One Protein May Hold the Key

In research published online April 8 in the Journal of Neuroscience, the calcitonin gene-related peptide (CGRP) is implicated in the development of migraine symptoms caused pain responses in female rodents, but not in males, when introduced into the meninges, the protective tissue layers surrounding the brain. 

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TRP Channels and Migraine: Recent Developments and New Therapeutic Opportunities.

Migraine is the second-most disabling disease worldwide, and the second most common neurological disorder. Attacks can last many hours or days, and consist of multiple symptoms including headache, nausea, vomiting, hypersensitivity to stimuli such as light and sound, and in some cases, an aura is present.

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2019 AAPM Meeting Highlights from Practical Pain Management

Read articles about the latest pain research present at AAPM35 in Denver, March 6-10, 2019. 

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