Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

 Brief Summary:Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24/7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the investigators will test a new therapy for chronic pain that has potential for better, more enduring analgesia.

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Mount Sinai Researchers Identify Brain Protein That Promotes Maintenance of Chronic Pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, accordin...
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Multisociety Pain Group Comments on Proposed Radiation Regulations in Colorado

AAPM participates in the Multisociety Pain Workgroup (MPW), a coalition of medical specialty societies, comprising physicians dedicated to pain management. This group convened to review and comment on the Colorado Board ...
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Objective Marker of Chronic Pain on the Horizon

Brain scans focusing on spatial variations in cerebral blood flow correlated with the presence -- though not severity -- of chronic knee pain, researchers said. The findings could eventually lead to a "brain signature of...
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BioElectronics Announces Publication of a Study of the ActiPatch® Medical Device as an Effective Long Term Treatment for Chronic Pain

 BioElectronics Corporation, the maker of non-invasive electroceutical devices, is pleased to announce the publication of a study in the journal Pain Research and Management , titled " A Prospective Six-Month S...
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Chronic Pain is a Huge Problem Nationwide, it’s Time for Fresh Approaches

  The medical community is turning to other approaches for chronic pain, including increasing patient support and education and improving overall wellness, perhaps with alternative treatments. Full story.

Noninvasive Nonpharmacological Treatments for Chronic Pain: An Update

The Evidence-based Practice Center (EPC) Program at the Agency for Healthcare Research and Quality (AHRQ) has posted the draft report for the systematic review on Noninvasive Nonpharmacological Treatments for Chronic Pai...
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Are Perioperative Interventions Effective in Preventing Chronic Pain After Primary Total Knee Replacement? A Systematic Review

For many people with advanced osteoarthritis, total knee replacement (TKR) is an effective treatment for relieving pain and improving function. Features of perioperative care may be associated with the adverse event of c...
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Tonic Suppression of the Mesolimbic Dopaminergic System by Enhanced Corticotropin-Releasing Factor Signaling Within the Bed Nucleus of the Stria Terminalis in Chronic Pain Model Rats

Although dysfunction of the mesolimbic dopaminergic system has been implicated in chronic pain, the underlying mechanisms remain to be elucidated. We hypothesized that increased inhibitory inputs to the neuronal pathway ...
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FDA Approves Abbott's "Low Dose," Recharge-Free Spinal Cord Stimulation System with up to Ten Year Battery Life for People Living with Chronic Pain

Abbott (NYSE: ABT) today announced the U.S. Food and Drug Administration (FDA) has approved the company's Proclaim XR™ recharge-free neurostimulation system for people living with chronic pain. The Proclaim XR platform o...
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Fighting Opioid Addiction and Chronic Pain Through Psychology

  AAPM members Magdalena Anitescu, MD, PhD, Madhuri Are, MD, Samer Narouze, MD, PhD , and Dennis J Patin, MD , are featured in this U.S. News and World Reports article: A Patient's Guide to Pain Management. Full sto...
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A New Model to Reach Vulnerable Older Adults With Pain Self-Management Support

Study Description: Brief Summary: Learning chronic pain self-management skills can help patients improve daily functioning and quality of life, while avoiding risks associated with opioids and other pharmacological treat...
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Chronic Pain, Couples, and Physical Activity

Chronic pain affects more than 50 million adults in the United States (Dahlhamer, Lucas, Zelaya, Nahin, Mackey, DeBar et al., 2018) and is estimated to cost the nation more than $560 billion dollars each year (Gaskin &am...
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Chronic Pain Research: Linking Psychology, Sociology, and Neuroscience

Despite its prevalence, scientists do not know why some people develop chronic pain. A new study approaches this question from all angles, exploring the role of money and the mind.

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Lower Back Pain? Self-Administered Acupressure Could Help

A recent study in Pain Medicine finds that acupressure, a traditional Chinese medicine technique, can improve chronic pain symptoms in the lower back. 

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Thwack! Insects Feel Chronic Pain After Injury

A study in the peer-reviewed journal Science Advances offers the first genetic evidence of what causes chronic pain in fruit flies and there is good evidence that similar changes also drive chronic pain in humans. Full s...
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Can You Reshape Your Brain's Response To Pain?

Repeated exposure to psychological trauma, or deep anxiety or depression — especially in childhood — can leave a physical imprint on the brain that can make some people more vulnerable to chronic pain, scientists say.&nb...
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Training Robots to Relieve Chronic Pain

Researchers at Swinburne University of Technology, Australia, have developed a collaborative robot system to automatically treat back, neck, and head pain caused by soft tissue injury.  Full story.
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New Opioid Speeds Up Recovery Without Increasing Pain Sensitivity or Risk of Chronic Pain

A novel opioid developed by researchers at Tulane University and the Southeast Louisiana Veterans Health Care System is as strong as morphine but isn't addictive and causes fewer side effects, according to a new study published in the Journal of Neuroinflammation

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Oregon Panel Drops Effort to Cut Opioids and Cover Chronic Pain

An Oregon committee has abandoned a controversial proposal that would have expanded treatment options for chronic pain patients under the Oregon Health Plan, but would have forced many to reduce dosages or discontinue pr...
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Oregon Panel Drops Effort to Cut Opioids and Cover Chronic Pain

An Oregon committee has abandoned a controversial proposal that would have expanded treatment options for chronic pain patients under the Oregon Health Plan, but would have forced many to reduce dosages or discontinue prescription opioids. 

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Anterior Nucleus of Paraventricular Thalamus Mediates Chronic Mechanical Hyperalgesia

Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the development of mechanical hyperalgesia in neuropathic and inflammatory pain models in mice.  

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New Chronic Pain Treatments Help the Whole Person

AAPM President Tim Lamer, MD contributed to this ​HealthyWomen article about the benefits of multidisciplinary chronic pain treatment, saying "It's more of a patient-centered, goal-oriented, holistic approach."

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UF Institute on Aging Study Shows Chronic Pain Might Accelerate Brain Aging

A new study led by a University of Florida Institute on Aging researcher has found the brain age of older adults with chronic pain had accelerated by an average of two years. 

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Depression, Obesity, Chronic Pain Could be Treated by Targeting the Same Key Protein

Major depression, obesity and chronic pain are all linked to the effects of one protein, called FKBP51. Researchers have now developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. 

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Self-Management Interventions for Chronic Pain Relief With Cancer Survivors (NCT03867760)

This study will evaluate the efficacy of a recorded hypnosis intervention in reducing chronic pain among cancer survivors and will explore its biological and psychological mechanisms. 

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New Target for Chronic Pain Relief Confirmed by Scientists

A research group at Hiroshima University observed a potential new target for chronic pain treatment. Further research using this receptor could lead to new, more effective drugs to use in pain-relieving treatment for chronic pain. 

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Where Does Chronic Pain Begin? Scientists Close in on Its Origins

Researchers cataloged variations in RNA expression in the dorsal root ganglia cells of patients differing by pain state and sex. Using RNA sequencing, a specialized form of gene sequencing, on those DRG cells yielded a l...
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State Hits Pause Button on Chronic Pain Proposal

Oregon health officials have delayed consideration of a controversial change under the Oregon Health Plan that could have forced many patients with chronic pain off opioids. 

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Managing Twin Crises in Chronic Pain and Prescription Opioids

AAPM Past President Sean Mackey, MD PhD, co-authored a BMJ editorial on how the national pain strategies are part of the solution in managing this twin crises. 

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Optimize Low Back Pain (NCT03859713)

The objective of this study is to improve health care for patients with chronic LBP and increase the likelihood that patients obtain outcomes that matter most to them. The investigators will accomplish our goal using a s...
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Peer-Support, Healing Hands Offers New Options to Patients with Chronic Pain on Prescription Opioids

A program providing group support, acupuncture, mindfulness, massage and gentle exercise may offer safe, extra relief to patients on prescription opioids, according to a study led by researchers at UC San Francisco. Full...
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Acupuncture Relief for Chronic Neck Pain (NCT03859011)

This study will measure the effectiveness of "usual care" for chronic neck pain as defined in the protocol, compared with usual care plus acupuncture for chronic neck pain. This study's hypothesis is that combining acupu...
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Interdisciplinary Pain Management Approach May Reduce Opioid and Benzodiazepine Use in Chronic Pain Patients

A four-week interdisciplinary pain management program for worker's compensation patients with chronic pain significantly reduced their opioid and benzodiazepine use, according to a new study.

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Smokers Are At High Risk for Low Back Pain, Hospitalization, and Opioid Use

Smokers are at high risk for low back pain, and also have higher rates of healthcare utilization and opioid use, and physicians should ask these patients about other comorbidities that may make their pain treatment more ...
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Virtual Reality Intervention Shows Promise for Back Pain Patients Who Are Afraid to be Active

A new virtual reality physical activity intervention may be effective for people with chronic low back pain who avoid activity because of fear, helping them to become physically active once again, according to a new stud...
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Upbeat Attitude May Be a Pain Fighter

AAPM President Jianguo Cheng, MD PhD , comments in this HealthDay News article about a recent study in JAMA Network Open . Dr. Cheng suggests that adding optimism training to treatments such as cognitive behavioral thera...
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Chronic Pain Patients: The Baby with the Bathwater?

AAPM longtime member David Nagel, MD , spoke to the New Hampshire Medical Society about unintended consequence of the battle against the opioid epidemic, and the negative impact on chronic pain patients. Full story .

The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)

This article describes the current consensus proposal by the International Association for the Study of Pain (IASP) and the International Society of Physical and Rehabilitation Medicine (ISPRM) for a specific set of FPs ...
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New Medications Offer Improved Treatment for Alcohol Use Disorders, Chronic Pain, Mood Disorders

A team of researchers from Purdue University discovered that two peptides, which are naturally metabolic products of Rubisco, a large protein found in many plants like spinach, may aid in the development of new medicatio...
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