Case Series: Deep Brain Stimulation for Facial Pain

Deep brain stimulation (DBS) has been used for chronic pain for decades, but its use is limited due to a lack of reliable data about its efficacy for specific indications. Full story .

Congratulations to Inaugural AAPM Early Investigator Research Grant Recipient, Ben Alter, MD PhD

June 17, 2020, CHICAGO -   The AAPM Early Investigator Research Grant was created in partnership with US WorldMeds to support preliminary or pilot research projects relevant to a comprehensive, multidisciplinar...
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Neurobiologist Finds Potent Pain-Suppression Center in the Brain

A Duke University research team has found a small area of the brain in mice that can profoundly control the animals' sense of pain. The researchers found that general anesthesia also activates a specific subset of inhibi...
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Brain Activity in People With Chronic Neuropathic Pain and Spinal Cord Injury

The purpose of this research study is to learn more about how patterns of brain activity change during different thinking tasks and how these changes relate to the intensity and unpleasantness of the neuropathic pain that people with SCI experience.

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How Animals 'Dial-Up' the Pain They Experience from Certain Stimuli

Researchers in the Faculty of Biological Sciences, in collaboration with colleagues in the US and China, have discovered that, under certain conditions, the molecular sensors that respond to physical stimuli can be turbo...
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Investigate the Mechanisms, Predictors, and Prevention of Persistent Post-Traumatic Headache

This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain injury, and identify...
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Noninvasive Brain Stimulation for Pain Relief

Non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS), is be applied to healthy human subjects, acute pain patients, and chronic pain patients to inv...
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How the Brain Balances Pleasure and Pain

Researchers have zeroed in on the ventral pallidum, an information-processing hub in the brains of mice to discover how neurons there influence the animals' motivation to either seek pleasurable experiences or avoid nega...
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Mount Sinai Researchers Identify Brain Protein That Promotes Maintenance of Chronic Pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, accordin...
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Objective Marker of Chronic Pain on the Horizon

Brain scans focusing on spatial variations in cerebral blood flow correlated with the presence -- though not severity -- of chronic knee pain, researchers said. The findings could eventually lead to a "brain signature of...
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New Research Offers a Minimally Invasive Approach to Deep Brain Stimulation

The development of a less invasive technique to precisely control the activity of neurons nestled deep in the brain could help usher in the next-generation of noninvasive brain stimulation technologies. Full story.  ...
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The Association Between Antidepressant Treatment and Brain Connectivity in Two Double-Blind, Placebo-Controlled Clinical Trials: A Treatment Mechanism Study

Antidepressant medications offer an effective treatment for depression, yet nearly 50% of patients either do not respond or have side-effects rendering them unable to continue the course of treatment. Mechanistic studies...
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Shifting Brain Circuits in Pain Chronicity

The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long-term brain changes. Here we focused on the p...
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