Noninvasive Brain Stimulation for Pain Relief

Non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS), is be applied to healthy human subjects, acute pain patients, and chronic pain patients to inv...
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How the Brain Balances Pleasure and Pain

Researchers have zeroed in on the ventral pallidum, an information-processing hub in the brains of mice to discover how neurons there influence the animals' motivation to either seek pleasurable experiences or avoid nega...
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Mount Sinai Researchers Identify Brain Protein That Promotes Maintenance of Chronic Pain

A protein called RGS4 (Regulator of G protein signaling 4) plays a prominent role in the maintenance of long-term pain states and may serve as a promising new target for the treatment of chronic pain conditions, accordin...
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Objective Marker of Chronic Pain on the Horizon

Brain scans focusing on spatial variations in cerebral blood flow correlated with the presence -- though not severity -- of chronic knee pain, researchers said. The findings could eventually lead to a "brain signature of...
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New Research Offers a Minimally Invasive Approach to Deep Brain Stimulation

The development of a less invasive technique to precisely control the activity of neurons nestled deep in the brain could help usher in the next-generation of noninvasive brain stimulation technologies. Full story.  ...
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The Association Between Antidepressant Treatment and Brain Connectivity in Two Double-Blind, Placebo-Controlled Clinical Trials: A Treatment Mechanism Study

Antidepressant medications offer an effective treatment for depression, yet nearly 50% of patients either do not respond or have side-effects rendering them unable to continue the course of treatment. Mechanistic studies...
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Shifting Brain Circuits in Pain Chronicity

The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long-term brain changes. Here we focused on the p...
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