Enhanced Recovery After Spine Surgery: A Systematic Review.

Enhanced recovery after surgery (ERAS) is a multidimensional approach to improving the care of surgical patients using subspecialty- and procedure-specific evidence-based protocols. The literature provides evidence of the benefits of ERAS implementation, which include expedited functional recovery, decreased postoperative morbidity, reduced costs, and improved subjective patient experience.

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A Clinical Overview of Off-label Use of Gabapentinoid Drugs

The gabapentinoid drugs gabapentin and pregabalin were originally developed as antiseizure drugs but now are prescribed mainly for treatment of pain. For gabapentin, the only pain-related indication approved by the US Food and Drug Administration (FDA) is postherpetic neuralgia. For pregabalin, FDA-approved indications related to pain are limited to postherpetic neuralgia, neuropathic pain associated with diabetic neuropathy or spinal cord injury, and fibromyalgia.

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Assessment of the FDA Risk Evaluation and Mitigation Strategy for Transmucosal Immediate-Release Fentanyl Products

 Did the US Food and Drug Administration's (FDA's) Transmucosal Immediate-Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy (REMS) meet its goal of preventing inappropriate use of TIRF products, such a...
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Transcription Factor Sp4 Is Required for Hyperalgesic State Persistence

Understanding how painful hypersensitive states develop and persist beyond the initial hours to days is critically important in the effort to devise strategies to prevent and/or reverse chronic painful states. Read the a...
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Glial Ensheathment of the Somatodendritic Compartment Regulates Sensory Neuron Structure and Activity

Sensory neurons perceive environmental cues and are important of organismal survival. Peripheral sensory neurons interact intimately with glial cells. While the function of axonal ensheathment by glia is well studied, le...
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Effects of Microencapsulated Olfactory Ensheathing Cell Transplantation on Neuropathic Pain and P2X7 Receptor Expression in the L4-5 Spinal Cord Segment

The aim of this study was to determine the role of microencapsulated olfactory ensheathing cell (MC-OEC) transplantation in rats with sciatic nerve injury-induced pain, and its relationship with P2 × 7 receptor expressio...
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Use of Prescription Opioids and Initiation of Fatal 2-Vehicle Crashes

The prevalence of prescription opioids detected in fatally injured drivers has increased markedly in the past 2 decades in the United States. It is unclear whether driver use of prescription opioids plays a role in fatal...
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A New Painkiller Nanomedicine to Bypass the Blood-Brain Barrier and the Use of Morphine

The clinical use of endogenous neuropeptides has historically been limited due to pharmacokinetic issues, including plasma stability and blood-brain barrier permeability. In this study, we show that the rapidly metaboliz...
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Predicting Inadequate Postoperative Pain Management in Depressed Patients: A Machine Learning Approach

Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSR...
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Prevention of Prescription Opioid Misuse and Projected Overdose Deaths in the United States

What is the projected effect of lowering incident nonmedical prescription opioid use on the future trajectory of the opioid overdose crisis in the United States?

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The Pain of Sleep Loss: A Brain Characterization in Humans

Sleep loss increases the experience of pain. However, the brain mechanisms underlying altered pain processing following sleep deprivation are unknown. Moreover, it remains unclear whether ecologically modest night-to-nig...
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Gender Bias in Pediatric Pain Assessment

Accurate assessment of pain is central to diagnosis and treatment in healthcare, especially in pediatrics. However, few studies have examined potential biases in adult observer ratings of children's pain. Read the abstra...
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Pain Abstracts

Association of Prescribed Opioids with Increased Risk of Community-Acquired Pneumonia Among Patients With and Without HIV What is the association between prescribed opioids and community-acquired pneumonia requiring hosp...
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