Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine: A Randomized Clinical Trial

Source: JAMA Abstract: Importance: Fremanezumab, a fully humanized monoclonal antibody that targets calcitonin gene-related peptide, may be effective for treating episodic migraine. Conclusions and Relevance: Among patie...
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Clinical Practice Guidelines for Neck and Low Back Pain in Outpatient Physical Therapy

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Less is More When it Comes to Prescription Opioids for Hospital Patients, Study Finds

Source: Yale School of Medicine In a pilot study published in JAMA Internal Medicine , Yale researchers significantly reduced doses of opioid painkillers given to hospital patients. By delivering the opioids with a shot ...
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Top-Down Descending Facilitation of Spinal Sensory Excitatory Transmission from the Anterior Cingulate Cortex

Source: Nature Communications Abstract: Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem...
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Development and Course of Chronic Pain Over 4 Years in the General Population: The HUNT Pain Study

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Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED

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Drosophila Insulin Receptor Regulates the Persistence of Injury-Induced Nociceptive Sensitization

Source: Disease Models & Mechanisms Diabetes-associated nociceptive hypersensitivity affects diabetic patients with hard-to-treat chronic pain. Because multiple tissues are affected by systemic alterations in insulin...
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Body’s 'Natural Opioids' Affect Brain Cells Much Differently than Morphine

Source: University of California, San Francisco A new study led by UC San Francisco scientists shows that brain cells, or neurons, react differently to opioid substances created inside the body – the endorphins responsib...
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Vertebroplasty Versus Sham Procedure for Painful Acute Osteoporotic Vertebral Compression Fractures (VERTOS IV): Randomised Sham Controlled Clinical Trial

Source: BMJ Abstract: Objective: To assess whether percutaneous vertebroplasty results in more pain relief than a sham procedure in patients with acute osteoporotic compression fractures of the vertebral body. Conclusion...
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Selecting Effective Combinations of Treatment for Low Back Pain (SELECT LBP)

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