Lilly Announces Licensing Agreement for Non-Opioid Pain Asset from Centrexion Therapeutics

Eli Lilly and Company announced a license agreement to acquire the exclusive worldwide rights for CNTX-0290 from Centrexion Therapeutics Corporation, a company focused on developing non-opioid, non-addictive therapeutics for the treatment of chronic pain. CNTX-0290, is a novel, small molecule somatostatin receptor type 4 (SSTR4) agonist that is currently being studied in Phase 1 clinical testing as a potential non-opioid treatment for chronic pain conditions. 

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Functional Spectroscopy Mapping of Pain Processing Cortical Areas During Non-Painful Peripheral Electrical Stimulation of the Accessory Spinal Nerve

Peripheral electrical stimulation (PES), which encompasses several techniques with heterogeneous physiological responses, has shown in some cases remarkable outcomes for pain treatment and clinical rehabilitation. Howeve...
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Comparison of Movement Pattern Training and Manual Therapy for Prearthritic Hip Disorders

Study Description: Brief Summary: Specific Aims Significance: Intra-articular, prearthritic hip disorders (PAHD) result in substantial dysfunction in young adults and are proposed precursors to hip osteoarthritis (OA). Our long term goal is to develop effective treatment strategies for people with PAHD that will improve function, decrease pain and prevent or delay the onset of OA. The purpose of this study is to compare movement pattern training (MoveTrain) and manual therapy (ManTher) in their effect on post-treatment, patient-reported outcomes and targeted impairments thought to contribute to PAHD.

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Improvements in Chronic Low Back Pain after Basivertebral Nerve Ablation

Patients who decreased opioid use after undergoing basivertebral nerve (BVN) ablation were found to experience greater relief of chronic low back pain than those who increased opioid use, according to a study published i...
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The Neuroinflammatory Component of Negative Affect in Patients with Chronic Pain

Abstract: Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patients is linked to elevations in the brain levels of the glial marker 18 kDa translocator protein (TSPO), and changes in functional connectivity. 25 cLBP patients (42.4 ± 13 years old; 13F, 12M) with chronic low back pain (cLBP) and 27 healthy control subjects (48.9 ± 13 years old; 14F, 13M) received an integrated (i.e., simultaneous) positron emission tomography (PET)/magnetic resonance imaging (MRI) brain scan with the second-generation TSPO ligand [11C]PBR28.

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AMA Opioid Task Force Recommendations Offer Roadmap to Policymakers

The recommendations include tangible actions policymakers can take to help reduce barriers to evidence-based treatment and end the nation's opioid epidemic. AAPM is among the 25 specialty and state medical societies that...
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AMA

World Health Assembly of the WHO Approves 11th Version of the International Classification of Diseases (ICD-11), Including New Diagnostic Codes for Chronic Pain

  ICD-11 will improve patient care by facilitating multimodal pain treatment and by boosting efforts to measure the quality and effectiveness of care and new research on the prevalence and impact of chronic pain Ful...
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Voltage-gated Sodium Channels: Structures, Functions, and Molecular Modeling

Abstract: Voltage-gated sodium channels (VGSCs), formed by 24 transmembrane segments arranged into four domains, have a key role in the initiation and propagation of electrical signaling in excitable cells. VGSCs are involved in a variety of diseases, including epilepsy, cardiac arrhythmias, and neuropathic pain, and therefore have been regarded as appealing therapeutic targets for the development of anticonvulsant, antiarrhythmic, and local anesthetic drugs.

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Medical Schools Look to Educate the Next Generation of Doctors on Pain

WBUR public radio interview discusses how some medical schools are changing the way students learn about pain and addiction.  Full story.  
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Walking Without Pain: How a New Surgical Procedure is Giving Hope to Some Amputees

An amputee recently became the third patient in Canada to undergo osseointegration, a relatively new procedure aimed at giving amputees higher functionality, mobility and comfort. Full story.  
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