American Pain Society

The American Academy of Pain Medicine (AAPM) is disheartened to learn of the dissolution of the American Pain Society ( APS ). Over the past nearly 40 years, AAPM has been fortunate to serve alongside APS in shared effor...
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AMA House of Delegates Annual Meeting Update

Pain medicine was represented at the recent American Medical Association House of Delegates (HOD) Annual Meeting by AAPM delegate Robert Wailes, MD , and alternate delegate Donna Bloodworth, MD . Among topics discussed, ...
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AMA

FDA Gives First-Ever Indication for Device to Be Used for Patients with Functional Abdominal Pain Associated with Irritable Bowel Syndrome (IBS)

The IB-Stim is a non-surgical device that is placed behind the patient's ear during an outpatient visit and works by sending gentle electrical impulses into cranial nerve bundles located in the ear.  Full story. &nb...
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New AAPM SIG: Academic Pain Medicine

AAPM recently created a new Academic Pain Medicine Shared Interest Group. This SIG is dedicated to supporting academic pain medicine through: Deliberate mentorship of academic pain clinicians, under the rubric of faculty...
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Transfer of Complex Regional Pain Syndrome to Mice via Human Autoantibodies is Mediated by Interleukin-1–Induced Mechanisms.

 Complex regional pain syndrome (CRPS) is a poorly understood painful condition, which typically arises after distal limb trauma; 20% of patients may develop lifelong severe incessant pain with few therapeutic options. In this study, we show that immunoglobulin G autoantibodies from patients with severe, persistent CRPS, on transfer to hind paw-injured mice, elicit important features of the clinical condition and profound glial activation in pain-related brain regions. Blockade of the proinflammatory cytokine interleukin-1 (IL-1) both prevents and reverses these changes. Our findings suggest that antibody-mediated autoimmunity contributes to the development of severe CRPS after injury and that blockade of IL-1 actions may be an attractive therapeutic prospect. Investigation of autoantibody contribution to other unexplained chronic pain syndromes seems warranted.
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Association Between Medical Cannabis Laws and Opioid Overdose Mortality has Reversed Over Time

​Medical cannabis has been touted as a solution to the US opioid overdose crisis since Bachhuber et al. [M. A. Bachhuber, B. Saloner, C. O. Cunningham, C. L. Barry, JAMA Intern. Med. 174, 1668–1673] found that from 1999 to 2010 states with medical cannabis laws experienced slower increases in opioid analgesic overdose mortality. That research received substantial attention in the scientific literature and popular press and served as a talking point for the cannabis industry and its advocates, despite caveats from the authors and others to exercise caution when using ecological correlations to draw causal, individual-level conclusions.

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Associations Between Gabapentinoids and Suicidal Behavior, Unintentional Overdoses, Injuries, Road Traffic Incidents, and Violent Crime: Population Based Cohort Study in Sweden

Abstract: OBJECTIVE: To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, or both and road traffic incidents or offences), mental health (suicid...
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Trigeminal Autonomic Cephalalgias Presenting in a Multidisciplinary Tertiary Orofacial Pain Clinic

Abstract: Orofacial pain may have a variety of causes and offers a significant clinical challenge for its diagnosis and management. Objective: To assess the headache disorders presenting in a tertiary multidisciplinary o...
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Chronic Opioid Prescribing in Primary Care: Factors and Perspectives

Abstract: BACKGROUND: Primary care clinicians write 45% of all opioid prescriptions in the United States, but little is known about the characteristics of patients who receive them and the clinicians who prescribe opioid...
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Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients (NMES)

Study Description: Brief Summary: The present prospective trial is designed to evaluate the efficacy of CyMedica Orthopedics e-vive™ system, a multifunctional electrotherapy device providing neuromuscular electrical stim...
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