Depression, Obesity, Chronic Pain Could be Treated by Targeting the Same Key Protein

Major depression, obesity and chronic pain are all linked to the effects of one protein, called FKBP51. Researchers have now developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. 

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Next-Generation Single-Dose Antidotes for Opioid Overdoses

Scientists report that they are developing single-dose, longer-lasting opioid antidotes using polymer nanoparticles. 

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How Pain Tolerance and Anxiety Seem to Be Connected

A rare disorder in which a 71-year-old woman experiences no pain or anxiety, raises questions about the links between physical and psychological pain. 

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To Keep Leftover Opioids Out of Harm’s Way, Give Surgery Patients Special Disposal Bags, Study Shows

In a research letter in the new issue of JAMA Surgery, a team from the University of Michigan reports that providing special disposal bags doubled the percentage of patients who safely disposed of their unneeded opioids within six weeks of their operation. 

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Pairing Music with Medication Offers Potential Therapeutic Strategy to Manage Pain

Pairing music with ibuprofen improved analgesic outcomes in an inflammation pain mouse model by more than 90 percent, while the cannabidiol-music and galanin analog NAX 5055-music pairings significantly reduced inflammation by 70 percent. 

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Another Possible Consequence of the Opioid Epidemic: Hormone Deficiencies

Many people who use opioid medications long term do not produce enough testosterone or another important hormone, cortisol, according to a new study. 

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Enhanced Recovery After Spine Surgery: A Systematic Review.

Enhanced recovery after surgery (ERAS) is a multidimensional approach to improving the care of surgical patients using subspecialty- and procedure-specific evidence-based protocols. The literature provides evidence of the benefits of ERAS implementation, which include expedited functional recovery, decreased postoperative morbidity, reduced costs, and improved subjective patient experience.

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Robot an Effective Pain Management Tool for Premature Babies

 

Researchers have designed a therapeutic robot that simulates human skin-to-skin contact, helping reduce pain for babies in the neonatal intensive care unit.

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Association of a Risk Evaluation and Mitigation Strategy Program With Transmucosal Fentanyl Prescribing.

Transmucosal immediate-release fentanyl (TIRF) drugs are potent, rapid-acting opioids approved to treat breakthrough pain in patients with cancer who are tolerant to other around-the-clock opioid analgesics. In March 201...
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NIH to Test Experimental Drug to Curb Opioid Cravings

A clinical trial of an experimental drug designed to treat cravings associated with OUD has begun in the National Institutes of Health Clinical Center. The Phase I trial in healthy adults will assess the safety of the experimental compound, ANS-6637, and how it is processed in the body when given with another drug that is processed by the same liver enzyme pathway. 

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