Identify AAPM35 Sessions of Interest & Reserve Hotel Rooms by February 1

Three preconference courses featuring pain medicine best practices, medications management, and ultrasound-guided pain interventions – as well as more than 50 AAPM 35th Annual Meeting sessions – make up AAPM35 March 6-10 in Denver. As an AAPM member, you receive discounted registration and access to special on-site benefits, like a Member Lounge an...
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Benefits and Harms of Pregabalin in the Management of Neuropathic Pain: A Rapid Review and Meta-Analysis of Randomized Clinical Trials

Pregabalin has beneficial effects on some symptoms of neuropathic pain. However, its use significantly increases the risk of a number of adverse events and discontinuation due to adverse events. The quality of the evidence from journal publications is low. Read the abstract . 

Association of Pharmaceutical Industry Marketing of Opioid Products with Mortality From Opioid-Related Overdoses

This study identifies the association between direct-to-physician marketing of opioid products by pharmaceutical companies and mortality from prescription opioid overdoses across US counties. Read the abstract . 
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Phosphorylation-Deficient G-Protein-Biased μ-Opioid Receptors Improve Analgesia and Diminish Tolerance but Worsen Opioid Side Effects

Findings identify carboxyl-terminal multisite phosphorylation as key step that drives acute μ-opioid receptor desensitization and long-term tolerance. Read the abstract . 
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Polls for the 2019-20 AAPM Elections Are Open

There is still time to cast your vote before polls for the AAPM 2019-20 Leadership Elections close on Monday, February 4 . Active, voting members were sent an email from AAPM on January 4 with their unique voting link.

Statement from FDA Commissioner Scott Gottlieb, MD, on Unprecedented New Efforts to Support Development of Over-the-Counter Naloxone to Help Reduce Opioid Overdose Deaths

To encourage drug companies to enter the OTC market and increase access to naloxone, the FDA took an unprecedented step of developing a model Drug Facts label (DFL) with easy-to-understand pictograms on how to use the drug. Full story.
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Microglia Promote Increased Pain Behavior Through Enhanced Inflammation in the Spinal Cord During Repeated Social Defeat Stress

Clinical studies indicate that psychosocial stress contributes to adverse chronic pain outcomes in patients, but it is unclear how this is initiated or amplified by stress. Read the abstract . 
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The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)

This article describes the current consensus proposal by the International Association for the Study of Pain (IASP) and the International Society of Physical and Rehabilitation Medicine (ISPRM) for a specific set of FPs of chronic pain, which will have to be empirically validated in a next step. Read the abstract . 
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Mindful Action for Pain (NCT03800654)

Chronic pain, defined as persistent or episodic pain that does not resolve with treatment, affects up to 50% of Veterans, costs the nation between $560 and $635 billion dollars annually, and is associated with high rates of disability and low quality of life. According to the Veterans Health Administration (VHA), the goal of pain treatment is to im...
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Study Explores Dangerous Increase in Patients Mixing Opioids, Benzodiazepines or Z-Drugs

A new study found a startling 250 percent increase in Americans taking a dangerous combination of both opioids and benzodiazepines — a group of drugs commonly prescribed for pain, insomnia and anxiety — over a 15-year period. Full story .