Improvements in Chronic Low Back Pain after Basivertebral Nerve Ablation

Patients who decreased opioid use after undergoing basivertebral nerve (BVN) ablation were found to experience greater relief of chronic low back pain than those who increased opioid use, according to a study published i...
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The Neuroinflammatory Component of Negative Affect in Patients with Chronic Pain

Abstract: Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis that NA in pain patients is linked to elevations in the brain levels of the glial marker 18 kDa translocator protein (TSPO), and changes in functional connectivity. 25 cLBP patients (42.4 ± 13 years old; 13F, 12M) with chronic low back pain (cLBP) and 27 healthy control subjects (48.9 ± 13 years old; 14F, 13M) received an integrated (i.e., simultaneous) positron emission tomography (PET)/magnetic resonance imaging (MRI) brain scan with the second-generation TSPO ligand [11C]PBR28.

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AMA Opioid Task Force Recommendations Offer Roadmap to Policymakers

The recommendations include tangible actions policymakers can take to help reduce barriers to evidence-based treatment and end the nation's opioid epidemic. AAPM is among the 25 specialty and state medical societies that...
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World Health Assembly of the WHO Approves 11th Version of the International Classification of Diseases (ICD-11), Including New Diagnostic Codes for Chronic Pain

  ICD-11 will improve patient care by facilitating multimodal pain treatment and by boosting efforts to measure the quality and effectiveness of care and new research on the prevalence and impact of chronic pain Ful...
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Voltage-gated Sodium Channels: Structures, Functions, and Molecular Modeling

Abstract: Voltage-gated sodium channels (VGSCs), formed by 24 transmembrane segments arranged into four domains, have a key role in the initiation and propagation of electrical signaling in excitable cells. VGSCs are involved in a variety of diseases, including epilepsy, cardiac arrhythmias, and neuropathic pain, and therefore have been regarded as appealing therapeutic targets for the development of anticonvulsant, antiarrhythmic, and local anesthetic drugs.

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Medical Schools Look to Educate the Next Generation of Doctors on Pain

WBUR public radio interview discusses how some medical schools are changing the way students learn about pain and addiction.  Full story.  
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Walking Without Pain: How a New Surgical Procedure is Giving Hope to Some Amputees

An amputee recently became the third patient in Canada to undergo osseointegration, a relatively new procedure aimed at giving amputees higher functionality, mobility and comfort. Full story.  
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Study Shows Safety Initiative Decreases Opioid Use in VA Patients with Little Impact on Pain Scores

New research published in Anesthesiology reports that after an Opioid Safety Initiative (OSI) was implemented at the Veterans Health Administration, patients undergoing knee replacement surgery were prescribed significan...
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Phenol Neurolysis of Genicular Nerves for Chronic Knee Pain

Study Description: Brief Summary: Chronic knee pain from osteoarthritis (OA) is commonly treated with total knee arthroplasty (TKA) when conservative therapies fail to provide pain relief. More than 600,000 TKAs are performed in the U.S. annually, a number that continues to increase. A logistic-regression model suggests that the incidence rate of TKA will increase by 143% in the United States by 2050 compared to 2012. Although TKA is successful in reducing knee pain and joint stiffness in most cases, it can be associated with a 7-35% incidence of persistent refractory post-surgical knee pain.

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FDA Grants Theranica De Novo to Market First Smartphone-controlled Acute Migraine-relief Wearable Device

Theranica, a bio-medical technology company developing advanced electroceuticals for migraine and other pain disorders, announced today that the U.S. Food and Drug Administration (FDA) granted a De Novo request for its smartphone-controlled electroceutical, Nerivio Migra®, utilizing Remote Electrical Neuromodulation for the acute treatment of migraine. 

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