Multiple Brain Regions Moderate and Link Depressive Mood and Pain

  Researchers at University of California San Diego School of Medicine have identified specific regions of the brain that drive, influence, and moderate depressive mood and its relationship to perceiving physical pa...
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Efficacy of Headache Treatment Using Radiofrequency Ablation

Despite the availability of therapies, many headache syndromes remain refractory to symptomatic treatment, achieving incomplete resolution of pain, and patients with chronic headaches often pursue nonpharmacologic treatm...
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Targeted Muscle Reinnervation Reduces Limb Pain After Amputation

Patients undergoing the nerve preimplantation procedure had less pain than patients undergoing conventional amputations as measured by best, current, and residual pain scores. The nerve transplant group also experienced ...
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Mayo Clinic Orthopedist Shares Perspective on Regenerative Medicine

Regenerative science has advanced next-generation technologies from the research bench to potential clinical care options. But in the rigorous development of patient therapies, it is critical to validate the safety and e...
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Oral CGRP Drug Bests Placebo for Migraine Prevention

Atogepant, an investigational oral calcitonin gene-related peptide (CGRP) receptor antagonist for migraine prevention, led to fewer monthly migraine days in episodic monthly migraine patients, results of a phase IIb/III ...
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Kailo Labs Launches the World’s First Nanotech Bio-Antenna for Pain Relief

Kailo Labs, an Utah-based nanotech startup, has launched the world's first nanotechnology-based bio-antenna for easy pain relief.  Full story.  
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Diagnosis and Management of Sensory Polyneuropathy

 Sensory polyneuropathies, which are caused by dysfunction of peripheral sensory nerve fibers, are a heterogeneous group of disorders that range from the common diabetic neuropathy to the rare sensory neuronopathies. The presenting symptoms, acuity, time course, severity, and subsequent morbidity vary and depend on the type of fiber that is affected and the underlying cause. Damage to small thinly myelinated and unmyelinated nerve fibers results in neuropathic pain, whereas damage to large myelinated sensory afferents results in proprioceptive deficits and ataxia.
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Chemist IDs Possible Addiction-Free Pain Reliever

 A naturally occurring enzyme, called diacylglycerol lipase-beta, or DAGLb, is a possible new drug target for reducing pain. Full story.  

Chronic Use of Tramadol after Acute Pain Episode: Cohort Study

To determine the risk of prolonged opioid use in patients receiving tramadol compared with other short acting opioids. Opioid-naive patients undergoing elective surgery. Risk of persistent opioid use after discharge for patients treated with tramadol alone compared with other short acting opioids, using three commonly used definitions of prolonged opioid use from the literature: additional opioid use (defined as at least one opioid fill 90-180 days after surgery); persistent opioid use (any span of opioid use starting in the 180 days after surgery and lasting ≥90 days); and CONSORT definition (an opioid use episode starting in the 180 days after surgery that spans ≥90 days and includes either ≥10 opioid fills or ≥120 days' supply of opioids).

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Hospitals Testing Virtual Reality to Improve Pain Management

Hospitals are experimenting with virtual reality to see if it can reduce pain, enhance the effect of medication, and lower the chances a patient is admitted.  Full story.  
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