Abstract: The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture and defense, providing the basis for survival and rapid diversification of the now estimated 750+ species. A typical Conus venom contains hundreds to thousands of bioactive peptides known as conotoxins.
Brief Summary:Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24/7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the investigators will test a new therapy for chronic pain that has potential for better, more enduring analgesia.
With governments’ increasing efforts to curb opioid prescription use and limit dose below the Centers for Disease Control and Prevention (CDC)-recommended threshold of 90 morphine milligram equivalents per day, little is known about prescription opioid patterns preceding opioid use disorder (OUD) or overdose.
The Drug Enforcement Administration announced proposed regulations to improve DEA’s ability to oversee the production of dangerous drugs at the height of the national opioid crisis. This proposed regulation would further limit excess quantities of medications that might be vulnerable to diversion for illicit distribution and use.
AAPM President Tim J. Lamer, MD, is interviewed in this U.S. News & World Report, about the importance of taking time to research the types of pain management doctors and the treatments they provide their patients.
American Academy of Pain Medicine